53976-95-7Relevant academic research and scientific papers
A facile ring transformation of 4-oxazolone derivatives to new antiviral imidazo[ 1,2-a]pyrimidin-7-ones
Yadav,Pal
, p. 1034 - 1037 (2007/10/03)
Michael addition of nitrogen nucleophiles, 2-(arylimino)imidazolidines 3a,b to 4-arylidene-5(4H)oxazolones 4a-d followed by ring transformation of the isolable Michael adducts 5a-h yields new bicyclic compounds, 6-acet(or benz)amido- 5, 8-diaryl-2,3,5,6-tetrahydro-7H-imidazo[1,2-a]pyrimidin-7-ones 6a-h in one-pot. The formation of Michael adducts 5a-h and their ring transformation to 6a-h are highly diastereoselective. Compounds 6e-f exhibit 100% in vitro disease control (equivalent to Virazole) against Corn virus, Bean virus and Cucumber mosaic virus at 1000 ppm concentration.
