5398-91-4

Usage

Uses

Used in Organic Synthesis:
(naphthalen-1-ylsulfanyl)acetonitrile is used as a synthetic building block for the creation of more complex organic molecules. Its naphthalene and acetonitrile moieties allow it to participate in a wide range of chemical reactions, making it a versatile component in organic synthesis.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, (naphthalen-1-ylsulfanyl)acetonitrile is used as a key intermediate in the development of new drugs. Its unique structural features may contribute to the design of novel therapeutic agents with specific biological activities.
Used in Agrochemicals:
(naphthalen-1-ylsulfanyl)acetonitrile is also utilized as a starting material or intermediate in the synthesis of agrochemicals, such as pesticides and herbicides. Its chemical properties enable the development of effective compounds for agricultural applications.
Used in Materials Science:
Within the field of materials science, (naphthalen-1-ylsulfanyl)acetonitrile may find applications in the development of new materials with specific properties, such as improved conductivity, strength, or stability. Its structural characteristics can be exploited to create materials with tailored properties for various applications.
Further research and development are necessary to fully explore the potential uses and properties of (naphthalen-1-ylsulfanyl)acetonitrile, as it may lead to the discovery of additional applications and benefits in different industries.

Upstream product

• 529-36-2 1-Naphthalenethiol 
• 107-14-2 chloroacetonitrile 
• 590-17-0 cyanomethyl bromide 

Downstream Products

• 861612-00-2 2-(naphthalen-1-ylsulfonyl)-1-phenylethan-1-one 
• 91258-54-7 N-Hydroxy-2-(naphthalen-1-ylsulfanyl)-acetamidine 

Relevant academic research and scientific papers

Ureidopeptide-based Bronsted bases: Design, synthesis and application to the catalytic enantioselective synthesis of β-amino nitriles from (arylsulfonyl)acetonitriles

The addition of cyanoalkyl moieties to imines is a very attractive method for the preparation of β-amino nitriles. We present a highly efficient organocatalytic methodology for the stereoselective synthesis of β-amino nitriles, in which the key to success is the use of ureidopeptide-based Bronsted base catalysts in combination with (arylsulfonyl)acetonitriles as synthetic equivalents of the acetonitrile anion. The method gives access to a variety of β-amino nitriles with good yields and excellent enantioselectivities, and broadens the stereoselective Mannich-type methodologies available for their synthesis. Learning from peptides: A concise route for the catalytic enantioselective synthesis of β-amino nitriles has been achieved by using ureidopeptide-based Bronsted bases as catalysts in the Mannich reaction of N-Boc imines and (arylsulfonyl)acetonitriles (see scheme; Boc=tert-butoxycarbonyl, napht=naphthyl, TMS=trimethylsilyl).

ALLOSTERIC BINDING COMPOUNDS

The present invention relates to allosteric binding compounds of formula (I), especially for the treatment of CNS disorders, together with pharmaceutical compositions and methods of treatment including these compounds.

Rhodium(I)-catalyzed addition of arylboronic acids to (benzyl-/ arylsulfonyl)acetonitriles: Efficient synthesis of (Z)-β- sulfonylvinylamines and β-Keto sulfones

An efficient rhodium(I)-catalyzed addition of arylboronic acids to (benzyl-/arylsulfonyl)acetonitrile is described. Novel β-sulfonylvinylamine products are formed in a stereoselective fashion (Z-alkene). Upon hydrolysis, useful β-keto sulfones are obtained with a broad scope of aryl and sulfonyl substituents.

ALLOSTERIC BINDING COMPOUNDS

The present invention relates to allosteric binding compounds of formula (I), especially for the treatment of CNS disorders, together with pharmaceutical compositions and methods of treatment including these compounds.