539821-21-1

Basic information

• Product Name: 2-Thiophenecarboxylic acid, 3-amino-4-(3,4-dimethoxyphenyl)-, methyl ester
• CAS NO: 539821-21-1
• Molecular Formula: C14H15NO4S
• Molecular Weight: 293.343
• Mol File: 539821-21-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-Thiophenecarboxylic acid, 3-amino-4-(3,4-dimethoxyphenyl)-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Thiophenecarboxylic acid, 3-amino-4-(3,4-dimethoxyphenyl)-, methyl ester(539821-21-1)
• EPA Substance Registry System: 2-Thiophenecarboxylic acid, 3-amino-4-(3,4-dimethoxyphenyl)-, methyl ester(539821-21-1)

Safety Data

• Hazardous Substances Data: 539821-21-1(Hazardous Substances Data)

Upstream product

• 2365-48-2 Methyl thioglycolate 
• 7306-46-9 4-chloromethyl-1,2-dimethoxy-benzene 
• 93-03-8 (3,4-dimethoxyphenyl)methanol 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 93-17-4 3,4-dimethoxyphenylacetonitrile 
• 679425-80-0 2-cyano-2-(3,4-dimethoxyphenyl)vinylbenzene sulfonate 

Downstream Products

• 1198077-27-8 3-acetylamino-4-(3,4-dimethoxyphenyl)thiophene-2-carboxylic acid methyl ester 
• 1198077-28-9 C₂₁H₁₆ClNO₄S 
• 1198077-29-0 C₂₂H₁₉NO₆S 
• 1111737-74-6 methyl 3-bromo-4-(3,4-dimethoxyphenyl)thiophene-2-carboxylate 
• 1111737-71-3 7,8-dimethoxythieno[3,4-c]cinnoline-3-carboxylic acid methyl ester 
• 1111737-77-9 methyl 3-bromo-4-(4-methoxyphenyl)thiophene-2-carboxylate 
• 1111737-73-5 methyl 7-methoxythieno[3,4-c]cinnoline-3-carboxylate 
• 679426-24-5 4-(3,4-dimethoxyphenyl)-3-(pyrrol-1-yl)-2-thiophene azide 
• 679426-23-4 4-(3,4-dimethoxyphenyl)-3-(pyrrol-1-yl)-2-thiophene carboxylic acid 
• 679425-90-2 methyl 4-(3,4-dimethoxyphenyl)-3-(pyrrol-1-yl)-2-thiophene carboxylate 

Relevant articles and documents

Acid cyclization of amino-substituted heterocycles. Synthesis of 1,3-dioxo- pyrrolo[3,4-c]- and thieno[3,4-c]isoquino- lines and cinnolines

The reaction of 3-amino-4-(3,4-dimethoxyphenyl)maleimide and the methyl esters of 3-amino-4-(3,4-dimethoxyphenyl)-5-R-thiophene-2-carboxylic acids with carbonyl compounds and nitrous acid has been investigated. Dioxopyrrolo[3,4-c]- and thieno[3,4-c]isoqui

Design, synthesis and antiproliferative activity of tripentones: A new series of antitubulin agents

Structure-activity relationship studies of a new series of tripentones (thieno[2,3-b]pyrrolizin-8-ones), led us to prepare several derivatives with antiproliferative activities. The most promising 3-(3-hydroxy-4-methoxyphenyl)thieno[2,3-b]pyrrolizin-8-one 20 (leukemia L1210, IC50 = 15 nM) was shown to be a potent inhibitor of tubulin polymerization.