53989-32-5

Basic information

• Product Name: Norcannabinol-9-carboxylic acid, 11-
• Synonyms: Norcannabinol-9-carboxylic acid, 11-
• CAS NO: 53989-32-5
• Molecular Formula: C21H24O4
• Molecular Weight: 340.41
• Mol File: 53989-32-5.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Norcannabinol-9-carboxylic acid, 11-(CAS DataBase Reference)
• NIST Chemistry Reference: Norcannabinol-9-carboxylic acid, 11-(53989-32-5)
• EPA Substance Registry System: Norcannabinol-9-carboxylic acid, 11-(53989-32-5)

Safety Data

• Hazardous Substances Data: 53989-32-5(Hazardous Substances Data)

Upstream product

• 89368-15-0 5'-bromo-2'-(1-hydroxy-1-methylethyl)-4-pentylbiphenyl-2,6-diol 
• 124-38-9 carbon dioxide 
• 89368-16-1 9-bromo-6,6-dimethyl-3-pentyl-6H-dibenzopyran-1-ol 

Downstream Products

• 30432-08-7 7-Hydroxy-cannabinol 

Relevant articles and documents

Cannabinol derivatives: Binding to cannabinoid receptors and inhibition of adenylylcyclase

Several derivatives of cannabinol and the 1,1-dimethylheptyl homolog (DMH) of cannabinol were prepared and assayed for binding to the brain and the peripheral cannabinoid receptors (CB1 and CB2), as well as for activation of CB1- and CB2-mediated inhibition of adenylylcyclase. The DMH derivatives were much more potent than the pentyl (i.e., cannabinol) derivatives. 11-Hydroxycannabinol (4a) was found to bind potently to both CB1 and CB2 (K(i) values of 38.0 ± 7.2 and 26.6 ± 5.5 nM, respectively) and to inhibit CB1-mediated adenylylcyclase with an EC50 of 58.1 ± 6.2 nM but to cause only 20% inhibition of CB2-mediated adenylylcyclase at 10 μM. It behaves as a specific, though not potent, CB2 antagonist. 11- Hydroxycannabinol-DMH (4b) is a very potent agonist for both CB1 and CB2 (K(i) values of 100 ± 50 and 200 ± 40 pM; EC50 of adenylylcyclase inhibition 56.2 ± 4.2 and 207.5 ± 27.8 pM, respectively).