54012-56-5

Usage

Uses

Used in Pharmaceutical Industry:
N-(3,4-DICHLOROPHENYL)MALEAMIC ACID is used as a precursor for the synthesis of pharmaceuticals for its versatile chemical structure and reactivity.
Used in Agrochemical Industry:
N-(3,4-DICHLOROPHENYL)MALEAMIC ACID is used as a precursor for the synthesis of agrochemicals to develop new compounds for agricultural applications.
Used in Corrosion Inhibition:
N-(3,4-DICHLOROPHENYL)MALEAMIC ACID is used as a potential corrosion inhibitor to protect materials from degradation in various industrial settings.
Used in Organic Reactions:
N-(3,4-DICHLOROPHENYL)MALEAMIC ACID is used as a versatile building block in various organic reactions to produce other organic compounds and materials.

InChI:InChI=1/C10H7Cl2NO3/c11-7-2-1-6(5-8(7)12)13-9(14)3-4-10(15)16/h1-5H,(H,13,14)(H,15,16)

Upstream product

• 108-31-6 maleic anhydride 
• 95-76-1 m,p-dichloroaniline 

Downstream Products

• 19844-27-0 1-(3,4-dichlorophenyl)pyrrole-2,5-dione 
• 370572-36-4 3-chloro-1-(3,4-dichlorophenyl)-4-(4-methylpiperazin-1-yl)-1H-pyrrole-2,5-dione 

Relevant academic research and scientific papers

Tackling Pseudomonas aeruginosa Virulence by a Hydroxamic Acid-Based LasB Inhibitor

In search of novel antibiotics to combat the challenging spread of resistant pathogens, bacterial proteases represent promising targets for pathoblocker development. A common motif for protease inhibitors is the hydroxamic acid function, yet this group has often been related to unspecific inhibition of various metalloproteases. In this work, the inhibition of LasB, a harmful zinc metalloprotease secreted by Pseudomonas aeruginosa, through a hydroxamate derivative is described. The present inhibitor was developed based on a recently reported, highly selective thiol scaffold. Using X-ray crystallography, the lack of inhibition of a range of human matrix metalloproteases could be attributed to a distinct binding mode sparing the S1′ pocket. The inhibitor was shown to restore the effect of the antimicrobial peptide LL-37, decrease the formation of P. aeruginosa biofilm and, for the first time for a LasB inhibitor, reduce the release of extracellular DNA. Hence, it is capable of disrupting several important bacterial resistance mechanisms. These results highlight the potential of protease inhibitors to fight bacterial infections and point out the possibility to achieve selective inhibition even with a strong zinc anchor.

Potent Nematicidal Activity of Maleimide Derivatives on Meloidogyne incognita

Different maleimide derivatives were synthesized and assayed for their in vitro activity on the soil inhabiting, plant-parasitic nematode Meloidogyne incognita, also known as root-knot nematode. The compounds maleimide, N-ethylmaleimide, N-isopropylmaleimide, and N-isobutylmaleimide showed the strongest nematicidal activity on the second stage juveniles of the root-knot nematode with EC50/72h values of 2.6 ± 1.3, 5.1 ± 3.4, 16.2 ± 5.4, and 19.0 ± 9.0 mg/L, respectively. We also determined the nematicidal activity of copper sulfate, finding an EC50 value of 48.6 ± 29.8 mg/L. When maleimide at 1 mg/L was tested in combination with copper sulfate at 50 mg/L, we observed 100% mortality of the nematodes. We performed a GC-MS metabolomics analysis after treating nematodes with maleimide at 8 mg/L for 24 h. This analysis revealed altered fatty acids and diglyceride metabolites such as oleic acid, palmitic acid, and 1-monopalmitin. Our results suggest that maleimide may be used as a new interesting building block for developing new nematicides in combination with copper salts.

An optimized RAD51 inhibitor that disrupts homologous recombination without requiring michael acceptor reactivity

Homologous recombination (HR) is an essential process in cells that provides repair of DNA double-strand breaks and lesions that block DNA replication. RAD51 is an evolutionarily conserved protein that is central to HR. Overexpression of RAD51 protein is