54022-97-8

Usage

Uses

Used in Pharmaceutical Development:
5-(3-FLUORO-PHENYL)-FURAN-2-CARBOXYLIC ACID is used as a potential active pharmaceutical ingredient for the development of new drugs. Its unique structure and properties may contribute to the discovery of novel therapeutic agents with specific biological activities.
Used in Organic Synthesis:
In the field of organic chemistry, 5-(3-FLUORO-PHENYL)-FURAN-2-CARBOXYLIC ACID serves as a building block for the synthesis of more complex organic molecules. Its presence in various chemical reactions can lead to the formation of new compounds with diverse applications.
Used in Research and Development:
5-(3-FLUORO-PHENYL)-FURAN-2-CARBOXYLIC ACID is utilized in scientific research and development to explore its properties, potential applications, and interactions with other compounds. This research can lead to a better understanding of its role in chemical and biological systems, as well as the development of new technologies and products based on its unique characteristics.
Used in Chemical Industry:
5-(3-FLUORO-PHENYL)-FURAN-2-CARBOXYLIC ACID is employed as an intermediate in the chemical industry for the production of various chemical products. Its versatility and reactivity make it a valuable component in the synthesis of specialty chemicals, agrochemicals, and other industrial products.
Used in Drug Discovery:
In the drug discovery process, 5-(3-FLUORO-PHENYL)-FURAN-2-CARBOXYLIC ACID is used as a starting material or a key component in the design and synthesis of new drug candidates. Its unique structure and potential pharmacological activities can contribute to the development of innovative therapeutic agents with improved efficacy and selectivity.

InChI:InChI=1/C11H7FO3/c12-8-3-1-2-7(6-8)9-4-5-10(15-9)11(13)14/h1-6H,(H,13,14)

Upstream product

• 54023-07-3 5-(3-fluorophenyl)furan-2-carboxylic acid methyl ester 
• 2527-99-3 methyl 5-bromo-2-furoate 
• 768-35-4 3-fluorophenylboronic acid 
• 585-70-6 5-bromo-furan-2-carboxylic acid 
• 88-14-2 2-furanoic acid 
• 372-19-0 meta-fluoroaniline 

Downstream Products

• 500605-03-8 N-[(1S,2R,4R)-7-azabicyclo[2.2.1]hept-2-yl]-5-(3-fluorophenyl)-2-furamide Hydrochloride 
• 1354698-28-4 N-5-(3'-fluorophenyl)-2-furoyl-1H-1,2,4-triazole 
• 1354698-17-1 N-5-(3'-fluorophenyl)-2-furoyl-1H-pyrazole 
• 850796-45-1 C₂₃H₂₅FN₂O₆ 

Relevant academic research and scientific papers

Discovery of a series of 5-phenyl-2-furan derivatives containing 1,3-thiazole moiety as potent Escherichia coli β-glucuronidase inhibitors

Gut microbial β-glucuronidases have drawn much attention due to their role as a potential therapeutic target to alleviate some drugs or their metabolites-induced gastrointestinal toxicity. In this study, fifteen 5-phenyl-2-furan derivatives containing 1,3

2-furoylamide compound and preparation and application thereof

The invention discloses a 2-furancarboxamide compound and a preparation method and application thereof. The 2-furancarboxamide compound is obtained by reacting a compound as shown in a formula II with9H-pyridino[3,4-b]indole in the presence of an acid-bin

Design, synthesis, and electrophysiological evaluation of NS6740 derivatives: Exploration of the structure-activity relationship for alpha7 nicotinic acetylcholine receptor silent activation

The α7 nicotinic acetylcholine receptor (nAChR) silent agonists, able to induce receptor desensitization and promote the α7 metabotropic function, are emerging as new promising therapeutic anti-inflammatory agents. Herein, we report the structure–activity

Synthesis and bioactivity of phenyl substituted furan and oxazole carboxylic acid derivatives as potential PDE4 inhibitors

In this present study, a series of 5-phenyl-2-furan and 4-phenyl-2-oxazole derivatives were designed and synthesized as phosphodiesterase type 4 (PDE4) inhibitors. In vitro results showed that the synthesized compounds exhibited considerable inhibitory ac

Novel S-Thiazol-2-yl-furan-2-carbothioate Derivatives as Potential T3SS Inhibitors against Xanthomonas oryzae on Rice

Bacterial leaf blight (BLB) caused by Xanthomonas oryzae pv oryzae (Xoo) is considered as the most destructive disease of rice. The use of bactericides is among the most widely used traditional methods to control this destructive disease. The excessive an

Synthesis and SAR of 5-aryl-furan-2-carboxamide derivatives as potent urotensin-II receptor antagonists

The synthesis and biological evaluation as potential urotensin-II receptor antagonists of a series of 5-arylfuran-2-carboxamide derivatives 1, bearing a 4-(3-chloro-4-(piperidin-4-yloxy)benzyl)piperazin-1-yl group, are described. The results of a systemat

Synthesis and biological evaluation of 2,5-disubstituted furan derivatives as P-glycoprotein inhibitors for Doxorubicin resistance in MCF-7/ADR cell

Multidrug resistance (MDR) is a tendency in which cells become resistant to structurally and mechanistically unrelated drugs, which is mediated by P-glycoprotein (P-gp). It is one of the noteworthy problems in cancer therapy. As one of the most important

Synthesis and bioactivity of 3,5-dimethylpyrazole derivatives as potential PDE4 inhibitors

A series of 3,5-dimethylpyrazole derivatives containing 5-phenyl-2-furan moiety were designed and synthesized as phosphodiesterase type 4 (PDE4) inhibitors. Bioassay results showed that the title compounds exhibited considerable inhibitory activity agains

Tetrahydroquinoline and tetrahydroisoquinoline derivatives as potential selective PDE4B inhibitors

Tetrahydroquinoline and tetrahydroisoquinoline derivatives containing 2-phenyl-5-furan moiety were designed and synthesized as phosphodiesterase type 4 (PDE4) inhibitors. The bioassay results showed that title compounds showed good inhibitory activity aga

Synthesis and bioactivity of pyrazole and triazole derivatives as potential PDE4 inhibitors

A series of pyrazole and triazole derivatives containing 5-phenyl-2-furan functionality were designed and synthesized as phosphodiesterase type 4 (PDE4) inhibitors. The bioassay results showed that title compounds exhibited considerable inhibitory activit