54029-73-1

Upstream product

• 54394-50-2 2-Nitro-4-phenylsulfinyl-anilin 
• 7440-44-0 pyrographite 
• 54029-72-0 2-amino-1-nitro-4-phenylsulfinylbenzene 

Downstream Products

• 66608-42-2 4-Phenylsulfinyl-N,N'-bis-(N-diethoxyphosphoryl-thiocarbamoyl)-1,2-phenylendiamin 
• 54394-06-8 1,2-bis-(3-carbomethoxy-2-thioureido)-4-phenylsulfinylbenzene 

Relevant academic research and scientific papers

Nitrodiaryl sulfoxide derivatives, process for their preparation and pharmaceutical and pesticidal compositions containing them as active ingredient

The invention relates to a new process for the preparation of aminodiaryl sulfoxide derivatives of the formula (I), STR1 wherein X is halogen, alkoxy having from 1 to 6 carbon atoms or a group --(N,R,R1), in which R and R1 are hydrogen or alkyl having from 1 to 6 carbon atoms, R2 is hydrogen, halogen, alkyl having from 1 to 6 carbon atoms, alkoxy having from 1 to 6 carbon atoms or phenyl or phenylthio both optionally substituted by one or more identical or different halogen(s) and/or amino group(s), and acid addition salts thereof. The compounds of formula (I) are pharmaceutically active, in particular are potent anthelmintics, or can be used as active ingredients in pesticidal compositions. The invention therefore relates to pharmaceutical and pesticidal compositions containing compounds of formula (I) or salts thereof as active ingredient. Compounds of formula (I), in which the substituents are as defined above, but if X stands for a group --N(R,R1) in which R and R1 both represent hydrogen, and X is in para-position related to the sulfoxide group, then R2 is other than hydrogen, halogen, alkyl having from 1 to 6 carbon atoms and alkoxy having from 1 to 6 carbon atoms, and the acid addition salts thereof, are new. These new compounds are also subject of the present invention.

5(6)-Benzene ring substituted benzimidazole-2-carbamate derivatives having anthelmintic activity

Carbalkoxythioureidobenzene derivatives represented by the following formula: STR1 where R is a lower alkyl group having 1 to 4 carbon atoms; R1 is --SR2, --SOR2, --SO2 R2, --OR2, --SCN, --SC(O)NR3 R4, or --M'(CH2)n MR7 where n is 1-4; R2 is lower alkyl having 1 to 6 carbon atoms, cycloalkyl having 3 to 7 carbon atoms, lower alkenyl or lower alkynyl having 3 to 6 carbon atoms, aralkyl or aryl, provided that when R1 is --SO2 R2, R2 is not aralkyl or phenyl; R3 and R4 are independently hydrogen or lower alkyl having 1 to 6 carbon atoms; Y is amino, nitro, acylamino where the acyl portion has 1 to 6 carbon atoms, --NHC(O) (CH2)m COOH where m is 1-6, or --NHC(S)NHCOOR; M and M' are independently O, S or STR2 and R7 is lower alkyl having 1 to 4 carbon atoms or aryl. The R1 substitution is either at the 4- or 5-position. The compounds are useful as pesticides, particularly as anthelmintic and antifungal agents.