54032-88-1

Basic information

• Product Name: 2-(4-Methoxy-phenyl)-4-methyl-thiazole-5-carboxylicacidethylester
• Synonyms: 2-(4-Methoxy-phenyl)-4-methyl-thiazole-5-carboxylicacidethylester;Ethyl 4-methyl-2-(4-methoxyphenyl)thiazole-5-carboxylate
• CAS NO: 54032-88-1
• Molecular Formula: C₁₄H₁₅NO₃S
• Molecular Weight: 277.34
• Mol File: 54032-88-1.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(4-Methoxy-phenyl)-4-methyl-thiazole-5-carboxylicacidethylester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Methoxy-phenyl)-4-methyl-thiazole-5-carboxylicacidethylester(54032-88-1)
• EPA Substance Registry System: 2-(4-Methoxy-phenyl)-4-methyl-thiazole-5-carboxylicacidethylester(54032-88-1)

Safety Data

• Hazardous Substances Data: 54032-88-1(Hazardous Substances Data)

Usage

Molecular structure

Consists of a thiazole ring with a methyl and methoxyphenyl group attached, as well as an ethyl ester functional group.

Type of compound

Organic compound.

Potential biological activity

May have antifungal or antibacterial properties due to the presence of the thiazole ring in its structure.

Use in research

Commonly used in pharmaceutical and medicinal research as a building block for the synthesis of other compounds.

Drug candidate potential

Its biological activity and structural features make it a promising candidate for further investigation as a potential drug.

Pharmacokinetic properties

The ethyl ester functional group suggests that the compound can be easily modified to improve its pharmacokinetic properties, making it more suitable for drug development.

Upstream product

• 2362-64-3 p-methoxythiobenzamide 
• 638-07-3 ethyl (2-chloroaceto)acetate 
• 84911-18-2 ethyl 2-bromoacetoacetate 
• 161797-99-5 (2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester) 
• 74-88-4 methyl iodide 
• 609-15-4 ethyl 2-chloro-3-oxo-butyrate 
• 3424-93-9 4-methoxyphenylacetamide 

Downstream Products

• 1384111-05-0 C₁₆H₁₈N₂O₄S 
• 161797-99-5 (2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester) 
• 82875-44-3 2-(4-methoxyphenyl)-4-methylthiazole-5carboxamide 
• 54001-35-3 2-bromo-1-(4-methyl-2- (4'-methoxyphenylthiazole-5-yl))ethan-1-one 

Relevant articles and documents

Design, synthesis, biological evaluation, common feature pharmacophore model and molecular dynamics simulation studies of ethyl 4-(phenoxymethyl)-2-phenylthiazole-5-carboxylate as Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2) inhi

SHP2 is a non-receptor protein tyrosine phosphatase (PTP) encoded by the PTPN11 gene involved in cell death pathway (PD-1/PD-L1) and cell growth and differentiation pathway (MAPK). Moreover, mutations in SHP2 have been implicated in Leopard syndrome (LS),

miRNA biosynthesis inhibitor

The invention provides a compound shown as a formula I, or a conformational isomer thereof, or an optical isomer thereof, or a pharmaceutically acceptable salt thereof. The compound can be tightly combined with related binding proteins in an miRNA biosynthesis process and can effectively inhibit the synthesis of miRNA-21. The prepared active compound provided by the invention can be used as an miRNA-21 inhibitor, and further as a potential drug for treating malignant tumors. The formula I is shown in the description.

Biphenyl heterocyclic derivatives, their preparation and their use as medicaments (by machine translation)

The present invention relates to a novel biphenyl heterocyclic derivative represented by a general formula (I) and a preparation method thereof and use of a pharmaceutical composition containing the derivative for preparation of a drug for treating diabetes. The biphenyl heterocyclic derivative has extremely excellent hypoglycemic activity in vivo, and excellent in vivo safety and low liver toxicity risk of the compound having such a structure are unexpectedly found, and the novel biphenyl heterocyclic derivative may be used for preventing or treating diabetes.