2362-64-3

Basic information

• Product Name: 4-METHOXYTHIOBENZAMIDE
• Synonyms: Benzenecarbothioamide,4-methoxy-;p-Anisamide,thio-;p-Methoxybenzothiamide;p-Methoxythiobenzamide;OTAVA-BB BB7020331318;4-METHOXYBENZOTHIOAMIDE;4-METHOXYBENZENE-1-CARBOTHIOAMIDE;4-METHOXYBENZENECARBOTHIOAMIDE
• CAS NO: 2362-64-3
• Molecular Formula: C₈H₉NOS
• Molecular Weight: 167.23
• Product Categories: Organic Building Blocks;Sulfur Compounds;Thiocarbonyl Compounds
• Mol File: 2362-64-3.mol
• Article Data: 57

Chemical Properties

• Melting Point: 145-149 °C(lit.)
• Boiling Point: 288.5 °C at 760 mmHg
• Flash Point: 128.3 °C
• Appearance: yellow powder
• Density: 1.194 g/cm³
• Vapor Pressure: 0.00233mmHg at 25°C
• Refractive Index: 1.619
• Storage Temp.: Refrigerator (+4°C)
• PKA: 13.02±0.29(Predicted)
• BRN: 1072444
• CAS DataBase Reference: 4-METHOXYTHIOBENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHOXYTHIOBENZAMIDE(2362-64-3)
• EPA Substance Registry System: 4-METHOXYTHIOBENZAMIDE(2362-64-3)

Safety Data

• Hazard Codes: Xi
• Statements: 43-20/22
• Safety Statements: 36-9
• RIDADR: 2811
• WGK Germany: 3
• PackingGroup: II
• Hazardous Substances Data: 2362-64-3(Hazardous Substances Data)

Usage

Description

4-methoxythio Benzamide is a synthetic intermediate useful for pharmaceutical synthesis. Thiobenzamides, including 4-methoxythio benzamide, are potent hepatotoxins in vivo.

Chemical Properties

yellow powder

Synthesis Reference(s)

Journal of the American Chemical Society, 82, p. 2656, 1960 DOI: 10.1021/ja01495a078The Journal of Organic Chemistry, 41, p. 148, 1976 DOI: 10.1021/jo00863a035

InChI:InChI=1/C8H9NOS/c1-10-7-4-2-6(3-5-7)8(9)11/h2-5H,1H3,(H2,9,11)

Upstream product

• 3424-93-9 4-methoxyphenylacetamide 
• 5909-67-1 tetramethyldiamidothiophosphoric acid 
• 62-55-5 thioacetamide 
• 874-90-8 4-methoxybenzonitrile 
• 123-11-5 4-methoxy-benzaldehyde 
• 333-20-0 potassium thioacyanate 
• 100-66-3 methoxybenzene 
• 67-56-1 methanol 
• 95642-52-7 4-hydroxy-2-p-(methoxyphenyl)-6H-1,3-thiazin-6-one 
• 105-07-7 4-cyanobenzaldehyde 
• 555-16-8 4-nitrobenzaldehdye 
• 144-55-8 sodium hydrogencarbonate 
• 110-91-8 morpholine 
• 141-84-4 2-thioxo-4-thiazolidinone 

Downstream Products

• 138330-03-7 2-(p-methoxyphenyl)-4-methylthiazole 
• 23421-57-0 4-chloromethyl-2-(4-methoxy-phenyl)-thiazole 
• 27088-84-2 2-(4-methoxyphenyl)-1,3-thiazole 
• 65823-62-3 2'-(4-methoxy-phenyl)-4-p-tolyl-[2,4']bithiazolyl 
• 65823-59-8 4-(4-chloro-phenyl)-2'-(4-methoxy-phenyl)-[2,4']bithiazolyl 
• 61108-26-7 2-(4-methoxy-phenyl)-4'-methyl-2'-phenyl-[4,5']bithiazolyl 
• 23821-85-4 [2-(4-methoxy-phenyl)-4-naphthalen-2-yl-thiazol-5-yl]-acetic acid 
• 61108-34-7 2'-(4-chloro-phenyl)-2-(4-methoxy-phenyl)-4'-methyl-[4,5']bithiazolyl 
• 3553-57-9 2-para-methoxyphenyl-1,3-thiazolidine-4,5-dione 
• 29942-12-9 6-[2-(4-methoxy-phenyl)-thiazol-4-yl]-benzothiazole 
• 91395-73-2 4-(2-chloro-ethyl)-2-(4-methoxy-phenyl)-thiazole 
• 23821-64-9 [2-(4-methoxy-phenyl)-4-phenyl-thiazol-5-yl]-acetic acid ethyl ester 
• 65823-91-8 1-(2-(4-methoxyphenyl)thiazol-4-yl)ethanone 
• 54001-06-8 1-(4-methyl-2-(4'-methoxyphenyl)thiazole-5-yl)ethane-1-one 

Relevant articles and documents

1-(2-(4-methoxyphenyl)thiazolyl-4-yl)ethylamine and synthesis method thereof

The invention belongs to the technical field of organic synthesis, and discloses 1-(2-(4-methoxyphenyl)thiazolyl-4-yl)ethylamine and a chemical synthesis method thereof. The method comprises the following steps: by taking 4-methoxybenzoic acid as a raw material, carrying out acylation, substitution, sulfonylation, substitution, hydrolysis, substitution, substitution and reduction reaction to prepare 1-(2-(4-methoxyphenyl)thiazolyl-4-yl)ethylamine. An efficient synthesis method is provided for synthesis of the compound.

COMPOUNDS FOR THIOL-TRIGGERED COS AND/OR H2S RELEASE AND METHODS OF MAKING AND USING THE SAME

Disclosed herein are embodiments of a compound that is capable of releasing COS and/or H2S upon reaction with a thiol-containing compound. The compound embodiments also can produce a detectable signal (e.g., a fluorescent signal) substantially concomitantly with COS and/or H2S release and/or can release an active agent, such as a therapeutic agent. Methods of making and using the compound embodiments also are disclosed.