54044-35-8

Upstream product

• 120-57-0 piperonal 
• 98-86-2 acetophenone 
• 644-34-8 (E)-3-(benzo[d][1,3]dioxol-5-yl)-1-phenylprop-2-en-1-one 
• 25131-60-6 2-phenacylisoquinolinium bromide 
• 5633-34-1 (benzoylmethylene)dimethylsulfurane 
• 2620-50-0 1,3-benzodioxol-5-ylmethyl amine 
• 536-74-3 phenylacetylene 
• 644-34-8 3,4-methylenedioxychalcone 
• 5667-47-0 phenacyldimethylsulfonium bromide 

Relevant academic research and scientific papers

TMSOTf-mediated Kr?hnke pyridine synthesis using HMDS as the nitrogen source under microwave irradiation

An efficient protocol for the preparation of pyridine skeletons has been successfully developed involving the TMSOTf/HMDS (trifluoromethanesulfonic acid/hexamethyldisilane) system for the intermolecular cyclization of chalcones under MW (microwave) irradiation conditions. This method provides a facile approach to synthesize 2,4,6-triaryl or 3-benzyl-2,4,6-triarylpyridines in good to excellent yields. Interestingly, the 2,6-diazabicyclo[2.2.2]oct-2-ene core was obtained by changing the acid additive to Sn(OTf)2, and the desired product was also confirmed using X-ray single-crystal diffraction analysis.

Synthesis of Kr?hnke pyridines through iron-catalyzed oxidative condensation/double alkynylation/amination cascade strategy

An efficient protocol for the synthesis of symmetrical and unsymmetrical 2,4,6-trisubstituted pyridines via oxidative cascade annulation of arylacetylenes with benzylamines has been developed. The reaction proceeds smoothly utilizing iron(II) triflate as a catalyst and molecular oxygen as an oxidant with broad substrate scope. Mechanistic studies reveal that the reaction may be experiences an oxidative condensation followed by double alkynylation and amination process.

Preparation method of 2,4,6-triaryl substituted pyridine derivative

The invention discloses a preparation method of a 2,4,6-triaryl substituted pyridine derivative. The preparation method comprises the following steps: taking a aryl methyl ketone compound and a benzylamine derivative as raw materials, taking tri(pentafluorobenzene)borane as a catalyst, and reacting for 6-24 hours under the oxygen condition at 80-160 DEG C to obtain the 2,4,6-triaryl substituted pyridine derivative. According to the preparation method has the main beneficial effects that the reaction raw materials are easily available; the consumption of the catalyst can be as low as 0.5%; theexperiment operation is simple; the target compound can be prepared by a one-pot process; the substrate universality is high; the 2,4,6-triaryl substituted pyridine derivative with different substituent groups can be built; the further derivatization research can be facilitated.

Novel solid-supported dimerization-heteroannulation of chalcones: simple and efficient synthesis of 2,4,6-triaryl-3-methylarylpyridines

2,4,6-Triaryl-3-methylarylpyridines were obtained, in 60-70% yield, by a novel one-pot solventless solid-supported dimerization-heteroannulation reaction of chalcones and compounds possessing terminal -CONH2 functionality, at 125-135 °C, using immobilized Bi(III) nitrate and Zn(II) chloride as co-catalyst. Initially, chalcones were prepared, in nearly quantitative yield, by a modified aldol condensation, in neutral aqueous medium, in the presence of p-toluenesodium sulfonate.

Studies on Cycloimmonium Ylides. Synthesis of Some 2,4,6-Triaryl-Substituted Pyridines via Isoquinolinium Ylides

(Aroylmethylene)isoquinolinium ylides on their reaction with different α,β-unsaturated ketones gave a wide variety of 2,4,6-triaryl-substituted pyridines which are expected to possess some potential biological activities.The reaction seemed to proceed via