540482-01-7Relevant academic research and scientific papers
Total synthesis and NMR conformational study of signal peptidase II inhibitors, globomycin and SF-1902 A5
Kiho, Toshihiro,Nakayama, Mizuka,Kogen, Hiroshi
, p. 1685 - 1697 (2007/10/03)
A stereoselective total synthesis of an antibiotic, globomycin (1a), and its congener, SF-1902 A5 (1b), was achieved. Two convergent macrocyclization routes via macrolactamization or macrolactonization to form 1a are described. A conformational study by means of NMR spectroscopy was performed in several solvents. The 1H NMR spectrum of 1a indicated that the amide proton of only the L-allo-Thr residue was involved in the hydrogen bonding. The structure in solution phase was different from the X-ray structure.
