64441-34-5

Upstream product

• 1509-34-8 D-allo-isoleucine 
• 694527-90-7 N-((2R,3S)-3-hydroxy-2-methylnonanoyl)-N-Me-L-Leu-L-allo-Ile-L-Ser(Bn)-OAllyl 
• 694527-60-1 (4R,5S)-3-[(2R,3S)-(3-hydroxy-2-methylnonanoyl)]-4-methyl-5-phenyloxazolidin-2-one 
• 247579-05-1 (2R,3S)-3-hydroxy-2-methylnonanoic acid 
• 111-71-7 heptanal 
• 694528-18-2 4-epi-24-O-benzyl-globomycin 
• 694527-80-5 (S)-3-Benzyloxy-2-{(2S,3S)-2-[(S)-2-(tert-butoxycarbonyl-methyl-amino)-4-methyl-pentanoylamino]-3-methyl-pentanoylamino}-propionic acid allyl ester 
• 694527-70-3 Boc-L-Ile-L-Ser(Bn)-OAll 
• 694527-92-9 N-((2R,3R)-3-[Boc-L-allo-Thr(TBS)-GlyO]-2-methylnonanoyl)-N-Me-L-Leu-L-Ile-L-Ser(Bn)-OAllyl 
• 742062-31-3 (S)-3-Benzyloxy-2-{(2S,3S)-2-[(S)-2-({(2R,3R)-3-[2-((2S,3S)-2-tert-butoxycarbonylamino-3-hydroxy-butyrylamino)-acetoxy]-2-methyl-nonanoyl}-methyl-amino)-4-methyl-pentanoylamino]-3-methyl-pentanoylamino}-propionic acid 
• 694527-82-7 N-((2R,3R)-3-hydroxy-2-methylnonanoyl)-N-Me-L-Leu-L-Ile-L-Ser(Bn)-OAllyl 
• 656256-01-8 N-Me-L-Leu-L-Ile-L-Ser(Bn)-OAllyl 
• 308279-65-4 (+)-(2R,3R)-3-hydroxy-2-methylnonanoic acid 
• 13139-16-7 N-(tert-butyloxycarbonyl)-L-isoleucine 

Relevant academic research and scientific papers

Solid phase synthesis of globomycin and SF-1902 A5

The syntheses of the natural lipocyclodepsipeptide-type antibiotics globomycin and SF-1902 A5 are reported, utilizing solid phase technology for the construction of the peptidic fragment and a new asymmetric methodology of epoxidation for the p

Structure-activity relationships of globomycin analogues as antibiotics

Globomycin (1a), a signal peptidase II inhibitor, and its derivatives show potent antibacterial activity against Gram-negative bacteria. The synthesis and antimicrobial activity of novel globomycin analogues are reported. The hydroxyl group in the L-Ser r

Total synthesis and NMR conformational study of signal peptidase II inhibitors, globomycin and SF-1902 A5

A stereoselective total synthesis of an antibiotic, globomycin (1a), and its congener, SF-1902 A5 (1b), was achieved. Two convergent macrocyclization routes via macrolactamization or macrolactonization to form 1a are described. A conformational study by means of NMR spectroscopy was performed in several solvents. The 1H NMR spectrum of 1a indicated that the amide proton of only the L-allo-Thr residue was involved in the hydrogen bonding. The structure in solution phase was different from the X-ray structure.

Synthesis and antimicrobial activity of novel globomycin analogues

Globomycin, a signal peptidase II inhibitor, and its derivatives show potent antibacterial activity against Gram-negative bacteria. The synthesis and antimicrobial activity of novel globomycin analogues are reported. One of the analogues showed a more pot