540524-67-2

Usage

Uses

Used in Organic Synthesis:
(2,6-Dimethylphenyl)methansulfonyl chloride is used as a reagent for the conversion of alcohols to alkyl chlorides, facilitating the synthesis of various organic compounds.
Used in Pharmaceutical Industry:
(2,6-Dimethylphenyl)methansulfonyl chloride is used as a building block in the preparation of sulfonamides and other pharmaceuticals, contributing to the development of new drugs and therapeutic agents.
Used in Fine Chemicals and Agrochemicals Synthesis:
(2,6-Dimethylphenyl)methansulfonyl chloride is utilized as a key component in the synthesis of various fine chemicals and agrochemicals, playing a crucial role in the production of specialty chemicals and agricultural products.
Safety Precautions:
Due to its corrosive and toxic nature, (2,6-Dimethylphenyl)methansulfonyl chloride should be handled with care to ensure safety during its use in different applications.

Upstream product

• 5402-60-8 2,6-dimethylbenzyl chloride 
• 62285-58-9 2,6-dimethylbenzyl alcohol 
• 83902-02-7 2,6-dimethylbenzyl bromide 

Downstream Products

• 82695-74-7 (E)-2,2',5,5'-tetramethylstilbene 
• 95586-35-9 C₁₈H₂₀ 
• 1032672-21-1 methyl 4-{2-[5-chloro-2-(2-{[(2,6-dimethylbenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]ethoxy}benzoate 
• 683813-36-7 methyl 4-{3-[5-chloro-2-(2-{[(2,6-dimethylbenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]propyl}benzoate 
• 1039627-98-9 C₂₂H₂₈N₂O₃S 
• 1039627-99-0 C₂₂H₂₈N₂O₃S 
• 867262-52-0 1-(2,6-dimethylphenyl)methanesulfonamide 
• 540524-68-3 methyl 4-({2-[5-chloro-2-(2-{[(2,6-dimethylbenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]ethyl}sulfonyl)benzoate 

Relevant academic research and scientific papers

Indole cytosolic phospholipase A2 α inhibitors: Discovery and in vitro and in vivo characterization of 4-{3-[5-chloro-2-(2-{[(3,4- dichlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]propyl} benzoic acid, efipladib

The optimization of a class of indole cPLA2α inhibitors is described herein. The importance of the substituent at C3 and the substitution pattern of the phenylmethane sulfonamide region are highlighted. Optimization of these regions led to the

Further improvement on sulfonamide-based ligand for catalytic asymmetric 2-haloallylation and allylation

(Chemical Equation Presented) The sulfonamide-based ligand B was found to exhibit an outstanding crystallinity and perform well as a ligand for Cr-mediated catalytic asymmetric 2-haloallylation and allylation. The new ligand has an appealing advantage ove

Methods for the use of inhibitors of cytosolic phospholipase A2 in the treatment of thrombosis

This invention provides methods for the use of substituted indole compounds of the general formula: and pharmaceutically acceptable salt forms thereof. The invention provides methods for the use of the compounds in the treating or preventing thrombosis in a mammal, or preventing progression of symptoms of thrombosis.

NOVEL SULFONAMIDE DERIVATIVE

A compound of the formula (1): wherein m, n and p is independently an integer of 0 to 4 with the proviso that 3 a?| m + n a?| 8; X is the formula: NR4, etc.; R1, R3 and R4 are a substituted or unsubstituted aryl group, etc.; R2 is a hydrogen atom, etc.; a, b, c, d, e and f are a hydrogen atom or a substituted or unsubstituted alkyl group, etc.; Y is the formula: -SO2-, etc.; and Z is an oxygen atom, etc.; or a prodrug thereof or a pharmaceutically acceptable salt of the same has an activity of potentiating an expression of a low density lipoprotein receptor and thus is useful as an agent for treating hyperlipidemia or arteriosclerosis.

Processes for the preparation of aryl-and heteroaryl-alkylsulfonyl halides

The present invention provides processes for the preparation of arylalkylsulfonyl halides and heteroarylalkylsufonyl halides of Formula I: Ar—R—SO2—X, that are useful as intermediates in the preparation of pharmaceuticals.

Process for making an aldehyde

A process for making an aromatic aldehyde in which a sulfoxide is reacted with a dihalogenated aromatic compound in the absence of an effective amount of an activating reagent. The aldehyde may then be used to make other compounds, such as a compound that acts as a cPLA inhibitor.

REACTION OF ARYLMETHANESULFONYL AND STYRYLMETHANESULFONYL CHLORIDES WITH TRIETHYLAMINE

A series of arylmethanesulfonyl chlorides were treated with triethylamine in THF to give stilbenes in excellent yields.Workup of the mixtures below 10 deg C permits isolation of stilbene episulfones which on warming decompose to yield the corresponding stilbenes stereospecifically.Application of the reaction to 9-fluorenylsulfonyl chloride affords bifluorenylidene, while trans-styrylmethanesulfonyl chloride gives 4,5-dihydro-4,5-diphenylthiepin 1,1-dioxide and 1,6-diphenylhexatriene.