540731-27-9Relevant academic research and scientific papers
Lactams as EP4 prostanoid receptor subtype selective agonists. Part 1: 2-Pyrrolidinones-stereochemical and lower side-chain optimization.
Elworthy, Todd R,Kertesz, Denis J,Kim, Woongki,Roepel, Michael G,Quattrocchio-Setti, Lina,Smith, David B,Tracy, Jahari Laurant,Chow, Audrey,Li, Fujun,Brill, Emma R,Lach, Leang K,McGee, Daren,Yang, Diana S,Chiou, San-San
, p. 1655 - 1659 (2007/10/03)
A series of 7-[(5R)-substituted 2-oxo-1-pyrrolidinyl]-heptanoic acids were prepared, their isomeric purity determined, and pharmacologically evaluated. Lactams with affinity for the EP(4) receptor displayed agonist behavior. The lower side-chain of the la
