540787-81-3Relevant articles and documents
Bicyclic[4.1.0]heptanes as phenyl replacements for melanin concentrating hormone receptor antagonists
Xu, Ruo,Li, Shengjian,Paruchova, Jaroslava,McBriar, Mark D.,Guzik, Henry,Palani, Anandan,Clader, John W.,Cox, Kathleen,Greenlee, William J.,Hawes, Brian E.,Kowalski, Timothy J.,O'Neill, Kim,Spar, Brian D.,Weig, Blair,Weston, Daniel J.
, p. 3285 - 3299 (2007/10/03)
Melanin concentrating hormone (MCH) receptor antagonists have been proposed as potential treatments of obesity. MCH receptor antagonists with a biphenylamine subunit have been reported previously at Schering-Plough. Herein, we report the discovery of bicy
Discovery of bicycloalkyl urea melanin concentrating hormone receptor antagonists: Orally efficacious antiobesity therapeutics
McBriar, Mark D.,Guzik, Henry,Xu, Ruo,Paruchova, Jaroslava,Li, Shengjian,Palani, Anandan,Clader, John W.,Greenlee, William J.,Hawes, Brian E.,Kowalski, Timothy J.,O'Neill, Kim,Spar, Brian,Weig, Blair
, p. 2274 - 2277 (2007/10/03)
Melanin concentrating hormone (MCH) is involved in regulation of food intake and energy homeostasis. Antagonists of the MCH receptor are expected to affect food intake and weight gain, making MCH-R1 an attractive target for obesity treatment. Herein, we r
Aminobenzimidazoles as selective melanin concentrating hormone receptor antagonists for the treatment of obesity and related disorders
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Page/Page column 11-12, (2008/06/13)
The present invention discloses compounds of formula I wherein Ar, Z, m, n, p, R1 and R8 are herein defined, said compounds being novel antagonists for melanin-concentrating hormone (MCH), as well as methods for preparing such compou
