54089-05-3Relevant academic research and scientific papers
Transition-metal-free synthesis of primary to tertiary carboxamides: A quick access to prodrug-pyrazinecarboxamide
Mete, Trimbak B.,Singh, Ankit,Bhat, Ramakrishna G.
supporting information, p. 4709 - 4712 (2017/11/21)
One-pot expedient and direct carbamoylation of heterocyclics is described. The transformation is realized via direct dehydrogenative aminocarbonylation of heterocyclic compounds under transition-metal-free conditions. This method is regioselective and the protocol is proved to be scalable on a gram scale. Further, the therapeutically useful antitubercular agent pyrazinecarboxamide is successfully synthesized by employing this protocol.
METHODS FOR THE PREPARATION OF TOPIROXOSTAT AND INTERMEDIATES THEREOF
-
Page/Page column 12, (2016/09/26)
The present invention relates to novel preparation methods for Topiroxostat through novel intermediates comprising novel methods for the formation of the triazole ring and for the cyanation of the pyridyl ring.
Oxidative ammonolysis of 2,4,6-collidine at vanadium-titanium oxide catalyst
Kagarlitsky,Krichevsky
, p. 315 - 317 (2007/10/03)
4-Cyanopyridine was synthesized from the readily obtainable 2,4,6-collidine by oxidative ammonolysis in the presence of vanadium-titanium oxide catalyst. Conditions under which the yield of the product amounted to 73% on the amount of the trimethylpyridin
A novel, selective free-radical carbamoylation of heteroaromatic bases by Ce(IV) oxidation of formamide, catalysed by N-hydroxyphthalimide
Minisci, Francesco,Recupero, Francesco,Punta, Carlo,Gambarotti, Cristian,Antonietti, Fabrizio,Fontana, Francesca,Pedulli, Gian Franco
, p. 2496 - 2497 (2007/10/03)
The Ce(IV)-NHPI system was used to generate a carbamoyl radical by oxidation of formamide; this nucleophilic radical has been successfully used in the carbamoylation of heteroaromatic bases.
Process for the preparation of 2,4-pyridine dicarboxylic acid
-
, (2008/06/13)
A process for the preparation of carboxamides of nitrogen-containing aromatic heterocyclic compounds from the corresponding N-heterocyclic compounds by reaction thereof with formamide in the presence of peroxodisulfuric acid or a peroxodisulfate.
