2-Pyridinecarboxamide,4-cyano-(9CI)

Base Information

• Chemical Name: 2-Pyridinecarboxamide,4-cyano-(9CI)
• CAS No.: 54089-05-3
• Molecular Formula: C7H5N3O
• Molecular Weight: 147.136
• Mol file: 54089-05-3.mol

Synonyms:2-Pyridinecarboxamide,4-cyano-(9CI)

Chemical Property of 2-Pyridinecarboxamide,4-cyano-(9CI)

Chemical Property:

• PSA: 79.77000
• LogP: 0.75248

Purity/Quality:

99%min ^*data from raw suppliers

4-CYANO-2-PYRIDINECARBOXAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Pyridinecarboxamide,4-cyano-(9CI)

There total 4 articles about 2-Pyridinecarboxamide,4-cyano-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

pyridine-4-carbonitrile (100-48-1) + formamide (77287-34-4,77287-35-5,60100-09-6) → 2-carbamoyl-4-cyanopyridine (54089-05-3)

Guidance literature:

With dipotassium peroxodisulfate; at 70 ℃; for 12h; regioselective reaction;

DOI:10.1016/j.tetlet.2017.11.006

Reference yield:

2,4,6-trimethyl-pyridine (108-75-8) → pyridine-4-carbonitrile (100-48-1) + 2-Picolinic acid (98-98-6) + 4-methylpyridine-2-carboxamide (54089-04-2) + 2-carbamoyl-4-cyanopyridine (54089-05-3)

Guidance literature:

With ammonium hydroxide; oxygen; vanadia; titanium(IV) oxide; at 300 ℃; Further Variations:; Temperatures; Product distribution;

DOI:10.1023/A:1023958625482

Reference yield:

pyridine-4-carbonitrile (100-48-1) + ammonium persulfate → 2-carbamoyl-4-cyanopyridine (54089-05-3)

Guidance literature:

With sulfuric acid; formamide; In water; acetonitrile;

upstream raw materials:

pyridine-4-carbonitrile

formamide

2,4,6-trimethyl-pyridine

Downstream raw materials:

pyridine-2,4-dicarboxylic acid

Refernces

• 1、 -. "METHODS FOR THE PREPARATION OF TOPIROXOSTAT AND INTERMEDIATES THEREOF". Page/Page column 12. . Retrieved 2016/09/26.
• 2、 Minisci, Francesco,Recupero, Francesco,Punta, Carlo,Gambarotti, Cristian,Antonietti, Fabrizio,Fontana, Francesca,Pedulli, Gian Franco. "A novel, selective free-radical carbamoylation of heteroaromatic bases by Ce(IV) oxidation of formamide, catalysed by N-hydroxyphthalimide". . p. 2496 - 2497. Retrieved 2007/10/03.