5409-45-0

Basic information

• Product Name: METHYL 2-(ACETYLAMINO)-5-NITROBENZOATE
• Synonyms: METHYL 2-ACETAMIDO-5-NITROBENZOATE;METHYL 2-(ACETYLAMINO)-5-NITROBENZOATE
• CAS NO: 5409-45-0
• Molecular Formula: C₁₀H₁₀N₂O₅
• Molecular Weight: 238.2
• Product Categories: Aromatic Esters;C10 to C11;Carbonyl Compounds;Esters
• Mol File: 5409-45-0.mol
• Article Data: 3

Chemical Properties

• Melting Point: 172.5-177.5 °C(lit.)
• Boiling Point: 468.9 °C at 760 mmHg
• Flash Point: 237.4 °C
• Appearance: /
• Density: 1.382 g/cm³
• Vapor Pressure: 5.74E-09mmHg at 25°C
• Refractive Index: 1.598
• CAS DataBase Reference: METHYL 2-(ACETYLAMINO)-5-NITROBENZOATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 2-(ACETYLAMINO)-5-NITROBENZOATE(5409-45-0)
• EPA Substance Registry System: METHYL 2-(ACETYLAMINO)-5-NITROBENZOATE(5409-45-0)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 5409-45-0(Hazardous Substances Data)

Usage

General Description

Methyl 2-(acetylamino)-5-nitrobenzoate is a synthetic, organic compound that belongs to the class of organic compounds known as nitrobenzenes. Nitrobenzenes are compounds containing a nitrobenzene moiety, which consists of a benzene ring with a nitro group. This specific compound has the presence of a nitro group (-NO2) and an acetylamino group (-NHCOCH3), making it a derivative of benzoic acid. Its molecular formula is C10H10N2O5. It is generally used in the field of chemistry for various types of research and experiments. However, detailed information about its specific uses, toxicity, and safety precautions are not readily available and would generally depend on the type and nature of the research being conducted.

InChI:InChI=1/C10H10N2O5/c1-6(13)11-9-4-3-7(12(15)16)5-8(9)10(14)17-2/h3-5H,1-2H3,(H,11,13)

Upstream product

• 3816-62-4 5-nitroanthranilic acid methyl ester 
• 75-36-5 acetyl chloride 
• 2719-08-6 methyl 2-(acetylamino)benzoate 

Downstream Products

• 632624-46-5 3-{2-[5-chloro-2-(2,3-difluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-6-acetylaminobenzoic acid 
• 632624-22-7 3-{2-[5-chloro-2-(4-bromo-2-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-6-acetylaminobenzoic acid 
• 632624-35-2 3-{2-[5-chloro-2-(2,6-difluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-6-acetylaminobenzoic acid 
• 632623-64-4 3-{2-[5-bromo-2-(4-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-6-acetylaminobenzoic acid 
• 632624-84-1 3-{2-[5-methyl-2-(4-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-6-acetylaminobenzoic acid 
• 632623-25-7 3-{2-[5-bromo-2-(benzyloxy)-phenyl]-5-methyl-pyrrol-1-yl}-6-acetylamino-benzoic acid 
• 632624-95-4 3-{2-[5-chloro-2-(benzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-6-acetylaminobenzoic acid 
• 80162-85-2 6-acetylamino-3-amino-benzoic acid methyl ester 
• 264260-06-2 4-hydroxy-6-nitroquinolin-2(1H)-one 

Relevant articles and documents

3-Aryl-4-hydroxyquinolin-2(1H)-one derivatives as type I fatty acid synthase inhibitors

A series of 3-aryl-4-hydroxyquinolin-2(1H)-ones with fatty acid synthase inhibitory activity was prepared. Starting from a derivative with an IC50 = 1.4 μM, SAR studies led to compounds with more than 70-fold increase in potency (IC50/sub

Non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase: Discovery and preliminary SAR of benzimidazole derivatives

Benzimidazole 5-carboxamide derivatives from a combinatorial screening library were discovered as specific inhibitors of the NS5B polymerase of the hepatitis C virus (HCV). Initial hit-to-lead activities taking advantage of high-throughput parallel synthetic techniques, identified a 1,2-disubstituted benzimidazole 5-carboxylic acid scaffold as the minimum core for biological activity. Potent analogues in this series inhibit the polymerase at low micromolar concentrations and provide an attractive 'drug-like' lead structure for further optimization and the development of potential HCV therapeutics.