5409-45-0

Usage

Uses

Used in Chemical Research:
METHYL 2-(ACETYLAMINO)-5-NITROBENZOATE is used as a research compound for [application reason] in the field of chemistry. Its unique structure and properties make it a valuable tool for studying chemical reactions and processes.
Used in Pharmaceutical Development:
In the pharmaceutical industry, METHYL 2-(ACETYLAMINO)-5-NITROBENZOATE is used as a potential intermediate or building block for the synthesis of new drug molecules. Its chemical properties may contribute to the development of novel therapeutic agents.
Used in Material Science:
METHYL 2-(ACETYLAMINO)-5-NITROBENZOATE is used as a component in the development of new materials, such as polymers or composites, due to its specific chemical characteristics. Its integration into these materials can lead to improved properties or new functionalities.
Note: The specific application reasons for METHYL 2-(ACETYLAMINO)-5-NITROBENZOATE may vary depending on the research context and the goals of the experiments or projects. The information provided here is a general overview, and more detailed information would be necessary to fully understand its uses in each application area.

InChI:InChI=1/C10H10N2O5/c1-6(13)11-9-4-3-7(12(15)16)5-8(9)10(14)17-2/h3-5H,1-2H3,(H,11,13)

Upstream product

• 2719-08-6 methyl 2-(acetylamino)benzoate 
• 3816-62-4 5-nitroanthranilic acid methyl ester 
• 75-36-5 acetyl chloride 

Downstream Products

• 264260-06-2 4-hydroxy-6-nitroquinolin-2(1H)-one 
• 632624-46-5 3-{2-[5-chloro-2-(2,3-difluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-6-acetylaminobenzoic acid 
• 632624-22-7 3-{2-[5-chloro-2-(4-bromo-2-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-6-acetylaminobenzoic acid 
• 632624-35-2 3-{2-[5-chloro-2-(2,6-difluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-6-acetylaminobenzoic acid 
• 632623-64-4 3-{2-[5-bromo-2-(4-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-6-acetylaminobenzoic acid 
• 632624-84-1 3-{2-[5-methyl-2-(4-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-6-acetylaminobenzoic acid 
• 632623-25-7 3-{2-[5-bromo-2-(benzyloxy)-phenyl]-5-methyl-pyrrol-1-yl}-6-acetylamino-benzoic acid 
• 632624-95-4 3-{2-[5-chloro-2-(benzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-6-acetylaminobenzoic acid 
• 80162-85-2 6-acetylamino-3-amino-benzoic acid methyl ester 

Relevant academic research and scientific papers

3-Aryl-4-hydroxyquinolin-2(1H)-one derivatives as type I fatty acid synthase inhibitors

A series of 3-aryl-4-hydroxyquinolin-2(1H)-ones with fatty acid synthase inhibitory activity was prepared. Starting from a derivative with an IC50 = 1.4 μM, SAR studies led to compounds with more than 70-fold increase in potency (IC50/sub

Synthesis and anticancer evaluation of bis(benzimidazoles), bis(benzoxazoles), and benzothiazoles

Four classes of UK-1 analogues were synthesized and their cytotoxicity testing against human A-549, BFTC-905, RD, MES-SA, and HeLa carcinoma cell lines was determined. The results revealed that UK-1 and four of these analogues (15-18) are potent against the cancer cell lines. In particular, compound 16 is more potent than UK-1 against A-549 and HeLa cell lines, and compounds 15, 17, and 18 selectively exhibit potent cytotoxic activity against the BFTV-905 cells (IC50 9.6 μM), A-549 cells (IC50 6.6 μM), and MES-SA cells (IC50 9.2 μM), respectively.

Non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase: Discovery and preliminary SAR of benzimidazole derivatives

Benzimidazole 5-carboxamide derivatives from a combinatorial screening library were discovered as specific inhibitors of the NS5B polymerase of the hepatitis C virus (HCV). Initial hit-to-lead activities taking advantage of high-throughput parallel synthetic techniques, identified a 1,2-disubstituted benzimidazole 5-carboxylic acid scaffold as the minimum core for biological activity. Potent analogues in this series inhibit the polymerase at low micromolar concentrations and provide an attractive 'drug-like' lead structure for further optimization and the development of potential HCV therapeutics.