5409-49-4Relevant academic research and scientific papers
PEG 400/cerium ammonium nitrate combined with microwave-assisted synthesis for rapid access to beta-amino ketones. an easy-to-use protocol for discovering new hit compounds
Rossino, Giacomo,Raimondi, Maria Valeria,Rui, Marta,Di Giacomo, Marcello,Rossi, Daniela,Collina, Simona
, (2018/04/06)
Compound libraries are important requirement in target-based drug discovery. In the present work, a small focused compound library based on β-aminoketone scaffold has been prepared combining microwave-assisted organic synthesis (MAOS) with polymer-assiste
AMINE COMPOUNDS AND THEIR PHARMACEUTICAL USE
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Page/Page column 10, (2011/04/25)
The present invention relates to a new amine compound or a pharmaceutically acceptable salt thereof, wherein the definitions of X, R1, R2 and n are given in the description, to a pharmaceutical composition containing the compound as active ingredient, and to use of the amine compound or its pharmaceutically acceptable salt for the manufacture of an anti-depressent drug.
Synthesis of some new thienyl and 1,3-thiazolyl-aminoketones with anti- inflammatory activity
Geronikaki, Athina A.,Hadjipavlou-Litina, Dimitra J.,Tzaki, Maria
, p. 266 - 271 (2007/10/03)
Eight thienyl and 1,3-thiazolyl-aminoketones were synthesised and tested as anti-inflammatory agents, pKa and log P were theoretically calculated. The compounds were tested for antioxidant activity, as hydroxyl radical scavengers, as superoxide anion scavengers and for their ability to interact with 1,1-diphenyl-2-picryl hydrazyl stable free radical (DPPH. The effects of the synthesised compounds on inflammation were studied using the carrageenan induced mice paw oedema model. Both anti-inflammatory and antioxidant activities depended on some structural characteristics of the synthesised compounds.
