5409-84-7

Usage

Structure

cyclohexanone derivative with a 4-chlorophenylsulfanyl group attached to the cyclohexanone ring

Uses

synthesis of pharmaceuticals, intermediate in the production of other chemical compounds

Applications

medicinal chemistry, chemical research

Potential activities

biological and pharmacological properties that warrant further investigation

Upstream product

• 106-54-7 p-Chlorothiophenol 
• 822-87-7 2-Chlorocyclohexanone 
• 1142-19-4 4,4'-dichlorodiphenyl disulfide 
• 110452-14-7 2-phenylthiocyclohexanone 
• 108-94-1 cyclohexanone 

Downstream Products

• 1415126-22-5 2-[(4-chlorophenyl)thio]-2-fluorocyclohexanone 

Relevant academic research and scientific papers

α-Organylchalcogenation of aldehydes and ketones with diorganyl dichalcogenides promoted by K3PO4

A new catalytic method for direct α-organylchalcogenation of aldehydes and ketones has been developed. When various aldehydes and ketones were allowed to react with diorganyl dichalcogenides in the presence of K 3PO4, under mild reac

Rhodium-catalyzed organothio exchange reaction of α-organothioketones with disulfides

RhH(PPh3)4 and 1,2-bis(diphenylphosphino)ethane (dppe) catalyzed the organothio exchange reaction of α-organothioketones and organic disulfides. The reaction was affected by the structure of the substrate: α-phenylthio and α-alkylthio aryl ketones reacted effectively with diaryl and dialkyl disulfides; α-phenylthio dialkyl ketones reacted with diaryl disulfides but not with dialkyl disulfides; diaryl disulfides with electron-donating p-substituents were more reactive than those with electron-withdrawing p-substituents.

N-Chlorosuccinimide as a versatile reagent for the sulfenylation of ketones: a facile synthesis of α-ketothioethers

The sulfenylation of ketones having α-hydrogens has been achieved using N-chlorosuccinimide (NCS) under mild reaction conditions to produce α-ketothioethers in excellent yields with high selectivity. The use of NCS makes this method quite simple, convenient and practical.