54090-08-3

Usage

Chemical Properties

clear light yellow to yellow liquid

InChI:InChI=1/C12H14F3O5P/c1-18-21(17,19-2)8-10(16)7-20-11-5-3-4-9(6-11)12(13,14)15/h3-6H,7-8H2,1-2H3

Upstream product

• 121-50-6 3-amino-4-chlorobenzotrifluoride 
• 98-56-6 4-chlorobenzotrifluoride 
• 121-17-5 2-chloro-3-nitro-5-trifluoromethylbenzene 

Downstream Products

• 201224-78-4 2-amino-5-(trifluoromethyl)benzenesulfonamide 
• 1698-38-0 2-benzylamino-5-trifluoromethylbenzenesulfonamide 
• 1019637-54-7 C₁₉H₁₆BrClF₄N₂O₂S 
• 1019637-53-6 C₁₉H₁₇BrClF₃N₂O₂S 
• 1053179-82-0 C₂₅H₂₅Cl₂F₃N₄O₅S 
• 1191926-53-0 1,1-dimethylethyl (3R)-3-({[2-chloro-5-(trifluoromethyl)phenyl]sulfonyl}amino)-1-pyrrolidinecarboxylate 
• 64903-10-2 1-(2-chloro-5-trifluoromethylphenylsulfonyl)-3-(4-methoxy-6-methyl-1,3,5-triazin-2-yl)urea 

Relevant academic research and scientific papers

HETEROCYCLIC COMPOUND

Provided is a heterocyclic compound that may have a GCN2 inhibitory action, and is expected to be useful for the prophylaxis or treatment of GCN2 associated diseases including cancer and the like. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof.

Research on controllable degradation of sulfonylurea herbicides

In order to seek ecologically safer and environmentally benign sulfonylurea herbicides (SU), insight into the structure/bioassay/soil degradation tri-factor relationship was first established. With the introduction of various groups (alkyl, nitro, halogen, cyano etc.) at the 5th position of its benzene ring, structural derivatives of chlorsulfuron were designed, synthesized, and evaluated for their herbicidal activity. The structures of the title compounds were confirmed by infrared spectroscopy, ultraviolet spectroscopy, 1H and 13C NMR, mass spectrometry, elemental analysis and X-ray diffraction. Bioassay results confirmed that most derivatives retained their superior herbicidal activities in comparison with chlorsulfuron. After investigating the soil degradation behavior of each molecule under set conditions, it was found that structures with electron-withdrawing substituents at the 5th position of the benzene ring retained their long degradation half-lives, yet the introduction of electron-donating substituents accelerated the degradation rate. These results will provide a valuable clue to further explore the potential controllable degradation of SU and other herbicides, and to discover novel herbicides that are favorable for environmentally and ecologically sustainable development.