54093-23-1

Usage

Uses

Used in Pharmaceutical Industry:
5-Bromo-2-chloro-6-methylpyrimidin-4-amine is used as an intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs and research compounds. Its unique structure allows for the creation of various derivatives that can be utilized in medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 5-Bromo-2-chloro-6-methylpyrimidin-4-amine is employed as an intermediate in the synthesis of agrochemicals, contributing to the development of new compounds for agricultural applications, such as pesticides and herbicides.
Used in Organic Chemistry Research:
5-Bromo-2-chloro-6-methylpyrimidin-4-amine is used as a reagent in organic chemistry for the formation of various derivatives. Its unique structure and properties make it a valuable tool for researchers in the field of organic chemistry, enabling the synthesis of new compounds and the exploration of novel chemical reactions.

InChI:InChI=1/C5H5BrClN3/c1-2-3(6)4(8)10-5(7)9-2/h1H3,(H2,8,9,10)

Upstream product

• 5424-21-5 2,4-dichloro-6-methylpyrimidine 
• 14394-60-6 2-chloro-6-methyl-pyrimidin-4-ylamine 
• 15018-56-1 5-bromo-6-methyluracil 
• 626-48-2 6-Methyluracil 
• 56745-01-8 5-bromo-2,4-dichloro-6-methylpyrimidine 

Relevant academic research and scientific papers

Thiazolo[4,5-d]pyrimidines: Synthesis and antibacterial evaluation

The reaction of 4-amino-5-bromo-2-chloro-6-methylpyrimidine (1) with carbon disulfide in the presence of KOH in DMF quantitatively gave 5-chloro-7-methylthiazolo[4,5- d] pyrimidine-2 (3 H)-thione (2) which was then alkylated at the sulfur atom with variou

POLYCYCLIC COMPOUNDS AS ALLOSTERIC SHP2 INHIBITORS

The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.

Fe(III) and cobalt(II) coordination compounds of 5-bromo-6-methyl-2- morpholinepyrimidinium-4-amine pyridine-2,6-dicarboxylate

New coordination compounds, (bmmpaH)[Fe(pydc)2] (EtOH) 0.8(H2O)0.2 (1), (8QH)[Fe(pydc)2] H2O (2), (2ampyH)2[Mn(pydc)2] H2O (3), (2ampyH)[Cr(pydc)2](2ampy)0.5 H2O (4), [Co(H2O)5-μ (pydc)Co(pydc)] 2H2O (5), [Ni(pydcH)2] H2O (6), and [Cu(pydcH)2] (7), where bmmpa, 8Q, 2ampy, pydcH2 are 5-bromo-6-methyl-2-morpholinepyrimidine-4- amine, 8-hydroxyquinoline, 2-amino-6-methylpyridine, and pyridine-2,6- dicarboxylic acid, respectively, have been synthesized and structurally characterized by elemental analyses, infrared, UV spectroscopic methods, and X-ray crystallography. Metal ions of 1 and 5 are six-coordinate with distorted octahedral geometries. Compound 1 is an anionic mononuclear complex and 5 is a binuclear compound constructed from cationic and anionic parts. The crystal data of 5 reveal that the cationic part is formed by five terminal waters and one μ-carboxylate oxygen O2 from the anionic portion and the anionic complex is built from two deprotonated (pydc)2- moieties. In the compounds, pydcH2 is tridentate by one nitrogen of pyridine ring and two oxygens of carboxylate.

New access to thiazolo[4,5-d]pyrimidine derivatives

4-Amino-5-bromo-2-substituted-aminopyrimidines are readily obtained from the newly prepared 5-bromo-2,4-dichloro-6-methylpyrimidine by sequential treatment with ethanolic ammonia and secondary amines. These compounds were successfully reacted with various isothiocyanates in the presence of sodamide in DMF to form the new thiazolo[4,5-d] pyrimidine derivatives.