56745-01-8

Usage

Uses

Used in Pharmaceutical Research:
5-Bromo-2,4-dichloro-6-methylpyrimidine is used as a building block for the synthesis of various biologically active compounds in pharmaceutical research. Its unique structure and functional groups make it a valuable component in the development of new drugs with potential therapeutic applications.
Used in Agrochemical Research:
In agrochemical research, 5-Bromo-2,4-dichloro-6-methylpyrimidine serves as an intermediate in the production of herbicides and insecticides. Its chemical properties allow for the creation of effective crop protection products that can help control pests and weeds, thereby improving agricultural productivity.
Used in Medicinal Chemistry:
5-Bromo-2,4-dichloro-6-methylpyrimidine has potential applications in the development of new drugs in the field of medicinal chemistry. Its versatile structure can be modified and combined with other chemical entities to create novel compounds with specific biological activities, contributing to the discovery of innovative therapeutic agents.
Used in Agricultural Chemistry:
As an important chemical in agricultural chemistry, 5-Bromo-2,4-dichloro-6-methylpyrimidine plays a crucial role in the development of new crop protection products. Its incorporation into herbicides and insecticides can lead to the creation of more effective and targeted pest control solutions, enhancing crop yield and quality.

InChI:InChI=1/C5H3BrCl2N2/c1-2-3(6)4(7)10-5(8)9-2/h1H3

Upstream product

• 15018-56-1 5-bromo-6-methyluracil 
• 626-48-2 6-Methyluracil 
• 6328-58-1 6-methyl-2-methylsulfanyl-3H-pyrimidin-4-one 
• 33238-63-0 5-bromo-6-methyl-2-(methylthio)pyrimidin-4(3H)-one 
• 15018-56-1 5-bromo-6-methyl-1H-pyrimidine-2,4-dione 

Downstream Products

• 7752-70-7 5-bromo-2,4-dimethoxy-6-methylpyrimidine 
• 3438-46-8 4-Methylpyrimidine 
• 5424-21-5 2,4-dichloro-6-methylpyrimidine 
• 5541-07-1 4-methoxy-6-methylpyrimidine 
• 54093-23-1 4-amino-5-bromo-2-chloro-6-methylpyrimidine 
• 928853-74-1 2-[(5-bromo-2-chloro-6-methylpyrimidin-4-yl)thio]benzenamine 
• 13036-57-2 2-chloro-4-methylpyrimidine 
• 1161010-34-9 7-chloro-5-methyl-3-(ethylsulfanyl)-1-phenyl-1H-pyrimido[4,5-e][1,3,4]thiadiazine 
• 1161010-33-8 7-chloro-5-methyl-3-(methylsulfanyl)-1-phenyl-1H-pyrimido[4,5-e][1,3,4]thiadiazine 

Relevant academic research and scientific papers

PYRIMIDINE AND FIVE-MEMBERED NITROGEN HETEROCYCLE DERIVATIVE, PREPARATION METHOD THEREFOR, AND MEDICAL USES THEREOF

The present invention relates to a pyrimidine and a five-membered nitrogen heterocycle derivative, a preparation method therefor, and the medical uses thereof. Particularly, the present invention relates to a pyrimidine and a five-membered nitrogen hetero

Design and synthesis of pyrimidinone and pyrimidinedione inhibitors of dipeptidyl peptidase IV

The discovery of two classes of heterocyclic dipeptidyl peptidase IV (DPP-4) inhibitors, pyrimidinones and pyrimidinediones, is described. After a single oral dose, these potent, selective, and noncovalent inhibitors provide sustained reduction of plasma DPP-4 activity and lowering of blood glucose in animal models of diabetes. Compounds 13a, 27b, and 27j were selected for development.

Fe(III) and cobalt(II) coordination compounds of 5-bromo-6-methyl-2- morpholinepyrimidinium-4-amine pyridine-2,6-dicarboxylate

New coordination compounds, (bmmpaH)[Fe(pydc)2] (EtOH) 0.8(H2O)0.2 (1), (8QH)[Fe(pydc)2] H2O (2), (2ampyH)2[Mn(pydc)2] H2O (3), (2ampyH)[Cr(pydc)2](2ampy)0.5 H2O (4), [Co(H2O)5-μ (pydc)Co(pydc)] 2H2O (5), [Ni(pydcH)2] H2O (6), and [Cu(pydcH)2] (7), where bmmpa, 8Q, 2ampy, pydcH2 are 5-bromo-6-methyl-2-morpholinepyrimidine-4- amine, 8-hydroxyquinoline, 2-amino-6-methylpyridine, and pyridine-2,6- dicarboxylic acid, respectively, have been synthesized and structurally characterized by elemental analyses, infrared, UV spectroscopic methods, and X-ray crystallography. Metal ions of 1 and 5 are six-coordinate with distorted octahedral geometries. Compound 1 is an anionic mononuclear complex and 5 is a binuclear compound constructed from cationic and anionic parts. The crystal data of 5 reveal that the cationic part is formed by five terminal waters and one μ-carboxylate oxygen O2 from the anionic portion and the anionic complex is built from two deprotonated (pydc)2- moieties. In the compounds, pydcH2 is tridentate by one nitrogen of pyridine ring and two oxygens of carboxylate.

New access to thiazolo[4,5-d]pyrimidine derivatives

4-Amino-5-bromo-2-substituted-aminopyrimidines are readily obtained from the newly prepared 5-bromo-2,4-dichloro-6-methylpyrimidine by sequential treatment with ethanolic ammonia and secondary amines. These compounds were successfully reacted with various isothiocyanates in the presence of sodamide in DMF to form the new thiazolo[4,5-d] pyrimidine derivatives.