54099-19-3

Upstream product

• 2094-72-6 1-Adamantanecarbonyl chloride 
• 108-00-9 N,N-dimethylethylenediamine 
• 828-51-3 1-Adamantanecarboxylic acid 

Relevant academic research and scientific papers

C H Bond Arylation of Diamondoids Catalyzed by Palladium(II) Acetate

We have developed an effective approach to 1,2-disubstituted diamondoids by palladium(II) acetate catalyzed functionalization of C H bond. Selective mono-arylation of the adamantane framework was achieved using picolylamide as a directing group in yields up to 87 %. Kinetic studies in combination with deuterium labeling experiments, competitive experiments and mass spectrometry contribute to the mechanistic understanding of the arylation process of alkanes with number of C H bonds neighboring the directing group. Triflic anhydride promoted cyclization of the directing group generates imidazo[1,5-a]pyridine derivatives. Acid-mediated removal of the directing group provides access to 2-aryl diamondoid carboxylic acids, which are common precursors for the synthesis of various bioactive compounds (drug candidates). (Figure presented.) .

Antiviral chemotherapeutic agents. XVII. Potential interferon inducers; adamantane derivatives

Several basic monofunctional adamantane derivatives are described in a systemic research on potential interferon inducers. Two showed slight antiviral activity against Mengovirus and one was marginally active as an interferon inducer in mice.