54100-47-9

Usage

Uses

Used in Organic Synthesis:
(4-tert-butylphenyl)(oxo)sulfanylphosphonium is used as a phase transfer catalyst for facilitating the transfer of organic molecules between aqueous and organic phases in chemical reactions. Its application in this context is valuable in various laboratory and industrial processes, enhancing the efficiency and selectivity of the reactions.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, (4-tert-butylphenyl)(oxo)sulfanylphosphonium may be utilized as a catalyst in the synthesis of complex organic molecules, including those with potential medicinal properties. Its ability to improve reaction conditions and selectivity can contribute to the development of new drugs and active pharmaceutical ingredients.
Used in Chemical Research:
(4-tert-butylphenyl)(oxo)sulfanylphosphonium is also used in chemical research as a tool to study reaction mechanisms and optimize reaction conditions. (4-tert-butylphenyl)(oxo)sulfanylphosphonium's unique structural features, including the tert-butylphenyl group and the oxo group, can provide insights into the influence of steric hindrance and electronic effects on reaction outcomes.
Used in Material Science:
(4-tert-butylphenyl)(oxo)sulfanylphosphonium may find applications in material science, particularly in the synthesis of novel materials with specific properties. The use of (4-tert-butylphenyl)(oxo)sulfanylphosphonium as a catalyst can help in the development of materials with tailored characteristics for various applications, such as in electronics, coatings, or advanced materials for energy storage and conversion.

Upstream product

• 644-97-3 Dichlorophenylphosphine 
• 6057-79-0 (S)-(-)-t-butyl(phenyl)phosphine oxide 
• 6002-45-5 t-butylphenylphosphinothioic acid 
• 98976-30-8 tert-Butylphenylphosphine oxide 
• 6002-45-5 (+/-)-tert-butyl(phenyl)phosphinothioic O-acid 

Downstream Products

• 115591-17-8 (+)-(S)-tert-butylphenylphosphinochloridothionate 
• 159811-78-6 (-)-(S)-tert-butylphenylphosphinobromidothionate 
• 128053-09-8 P(S)S_P(O)>-(-)-bis(t-butylphenyl)thiophosphinate 
• 107487-28-5 C₂₇H₂₉OPSSi 
• 6057-79-0 (S)-(-)-t-butyl(phenyl)phosphine oxide 
• 54100-52-6 C₁₀H₁₄ClOPS 
• 38802-08-3 (S)-(-)-tert-butylmethylphenylphosphine oxide 
• 133319-25-2 (S_p)-(E)-But-2-enyl-tert-butylphenylphosphine oxide 
• 21448-79-3 (R_P)-tert-butylphenylmethylphosphine oxide 
• 75213-01-3 t-BuPhP(O)Cl 

Relevant academic research and scientific papers

T -Butylphenyl-(1-Naphthyl)Phosphinothioic Acids and Their Selenium Analogs: Synthesis of the Racemic Mixtures and Attempts to Isolate the Enantiomers of t -Butyl-1-Naphthylphosphinothioic Acid

Synthesis of racemic t-butyl-1-naphthylphosphinothio(seleno)ic acids and attempts to isolate the enantiomers of t-butyl-1-naphthylphosphinothioic acid are described.

Chiral t-butylphenylphosphinothioic acid: A useful chiral solvating agent for direct determination of enantiomeric purity of alcohols, thiols, amines, diols, aminoalcohols and related compounds

Enantiomers of t-butylphenylphosphinothioic acid were found to be useful chiral solvating agents (CSAs) for 1H-NMR determination of enantiomeric excess (ee) of many classes of chiral organic compounds, such as alcohols, diols, thiols, mercaptoalcohols, amines, aminoalcohols, hydroxyacids and related compounds.

A new procedure for the synthesis of optically active t-butylphenylphosphinothioic acid

A new procedure for the synthesis of optically active t-butylophenylphosphinothioic acid as an enantiomerically pure dextrorotatory enantiomer having the absolute configuration (R), by a reaction of the racemate of secondary t-butylphenylphosphine oxide with elemental sulfur in the presence of a molar equivalent of the levorotatory enantiomer of enantiomerically pure (S)-α-phenylethylamine, is reported. It is obvious that with the use of the dextrorotatory enantiomer of α-phenylethylamine, the levorotatory enantiomer of this thioacid will be isolated.

Stereospecific nucleophilic substitution of optically pure H-phosphinates: A general way for the preparation of chiral P-stereogenic phosphine oxides

Contrary to the generally held view, it is found that the rapid epimerization of (-)-menthyl (RP)-phenylphosphinate under basic conditions is not due to the so far believed inherent stereolability of its corresponding anion but due to a reactio

Reaction of metallated tert-butyl(phenyl)phosphane oxide with electrophiles as a route to functionalized tertiary phosphane oxides: Alkylation reactions

P-Chiral tertiary phosphane oxides have been prepared from each of the secondary phosphane oxides racemic 1, (S(p))-(-)-4 and (Rp)-(+)-tert-butylphenylphosphane oxide (5) by lithiation with LDA or nBuLi, or sodiation with sodium hydride, in THF, and then by treatment with a series of primary alkyl halides. Doubly P-chiral ditertiary bis(phosphane oxides) are also obtained from these metallated secondary phosphane oxides by treatment with electrophiles based on straight-chain, tartrate-derived, and bishalomethylarene dihalides. In general, the bis-phosphane oxides are obtained in good yields. However, when the α,ω-dihalide bears an embedded heteroatom (O or Si), yields are diminished. The enantiomeric purity of each of the products was assessed through admixture with (R(p))- and (S(p))-tert-butyl(phenyl)phosphanylthioic acids and measurement of the tert-butyl resonances in the 1H-NMR spectra. In all cases, the act of metallation of the enantiomerically pure secondary phosphane oxide followed by its alkylation is not accompanied by detectable racemization. This method for preparing P-chiral tertiary phosphane oxides is therefore more straightforward than those described previously.

Srereoselective Synthesis and Stereochemistry of Optically Active tert-Butylphenylphosphine Sulfide

Stereoselective reduction of the mixed anhydride of tert-butylphenylphosphinothioic acid trifluoromethanesulfonic acid by sodium borohydride provides optically active tert-butylphenylphosphine sulfide of high optical purity.A synthesis of optically active