54110-95-1

Usage

Uses

Used in Organic Synthesis:
(1-(ETHOXYCARBONYL)-PROPYL)-TRIPHENYLPHOSPHONIUM BROMIDE is used as a catalyst for facilitating the formation of alkene products in the Wittig reaction, a widely used method for the synthesis of alkenes.
Used in Phosphonium Salt Derivatives Synthesis:
(1-(ETHOXYCARBONYL)-PROPYL)-TRIPHENYLPHOSPHONIUM BROMIDE is used as a reactant in the preparation of phosphonium salt derivatives, which are important intermediates in the synthesis of various organic compounds.
Used in Pharmaceutical Research:
(1-(ETHOXYCARBONYL)-PROPYL)-TRIPHENYLPHOSPHONIUM BROMIDE is used as a reactant in the preparation of phosphorane compounds, which have potential applications in the development of new molecules and pharmaceuticals.
Used in Medicinal Chemistry:
(1-(ETHOXYCARBONYL)-PROPYL)-TRIPHENYLPHOSPHONIUM BROMIDE is used as a building block for the development of new molecules with potential therapeutic properties, contributing to the advancement of medicinal chemistry.

Upstream product

• 603-35-0 triphenylphosphine 
• 533-68-6 2-bromobutyric acid ethyl ester 

Downstream Products

• 4702-34-5 isochroman-1-one 
• 83501-64-8 2-(1-Isochromanylmethylen)butansaeure-ethylester 
• 1206896-59-4 ethyl 4-phenyl-2-propyl-2,3-hexadienoate 
• 1206896-48-1 ethyl 2-ethyl-4-(p-tolyl)-2,3-butadienoate 
• 57470-18-5 ethyl 4-phenyl-2-ethyl-2,3-butadienoate 
• 1206896-65-2 4-(2-chloro-phenyl)-2-methyl-buta-2,3-dienoic acid ethyl ester 
• 1267984-30-4 ethyl 4-(p-bromophenyl)-2-ethyl-2,3-butadienoate 
• 22592-13-8 ethyl 2-(triphenylphosphoranylidene)butanoate 

Relevant academic research and scientific papers

Stereoselective Synthesis of Fused Vinylcyclopropanes by Intramolecular Tsuji-Trost Cascade Cyclization

A stereoselective intramolecular Tsuji-Trost cascade cyclization of (homo)allylic vicinal diacetates with a pendant β-ketoamide or related carbon nucleophile to give γ-lactam-fused vinylcyclopropanes is reported. In addition to two new rings, the products contain three new C-C stereocenters (two of which are quaternary) with a 9:1 dr. Moreover, the reaction proceeds in >94% enantiospecificity with optically enriched starting materials, using an inexpensive carbohydrate as the source of chirality.

PHOSPHONIUM ION CHANNEL BLOCKERS AND METHODS FOR USE

The invention provides compounds of Formula (I), or pharmaceutically acceptable salts thereof: The compounds, compositions, methods and kits of the invention are useful for the treatment of pain, itch, and neurogenic inflammation.

Metal-Free Transfer Hydroiodination of C-C Multiple Bonds

The design and a gram-scale synthesis of a bench-stable cyclohexa-1,4-diene-based surrogate of gaseous hydrogen iodide are described. By initiation with a moderately strong Br?nsted acid, hydrogen iodide is transferred from the surrogate onto C-C multiple bonds such as alkynes and allenes without the involvement of free hydrogen iodide. The surrogate fragments into toluene and ethylene, easy-to-remove volatile waste. This hydroiodination reaction avoids precarious handling of hydrogen iodide or hydroiodic acid. By this, a broad range of previously unknown or difficult-to-prepare vinyl iodides can be accessed in stereocontrolled fashion.

Α-calbonyl phosphorane manufacturing method

PROBLEM TO BE SOLVED: To provide a new method for producing α-carbonyl phosphorane, which is industrially advantageous, and which brings about a high yield and high purity with a simple operation. SOLUTION: In the reaction to synthesize an α-carbonyl phosphorane represented by general formula (I) by making a base act on an aqueous solution of an α-carbonyl phosphonium salt represented by general formula (II), the crystal of the α-carbonyl phosphorane is easily deposited by conducting the reaction with previous addition of a water-insoluble organic solvent (in formulas, Ar represents an optionally substituted aryl group, R1represents a hydrogen atom, an optionally substituted alkyl group or an optionally substituted aryl group, R2represents an optionally substituted alkyl group or an optionally substituted aryl group, and X-represents a counter anion). COPYRIGHT: (C)2012,JPOandINPIT

Lanosterol biosynthesis: The critical role of the methyl-29 group of 2,3-oxidosqualene for the correct folding of this substrate and for the construction of the five-membered D ring

Lanosterol synthase catalyzes the polycyclization reaction of (3S)-2,3-oxidosqualene (1) into tetracyclic lanosterol 2 by folding 1 in a chair-boat-chair-chair conformation. 27-Nor- and 29-noroxidosqaulenes (7 and 8, respectively) were incubated with this enzyme to investigate the role of the methyl groups on 1 for the polycyclization cascade. Compound 7 afforded two enzymatic products, namely, 30-norlanosterol (12) and 26-normalabaricatriene (13; 12/13 9:1), which were produced through the normal chair-boat-chair-chair conformation and an atypical chair-chair-boat conformation, respectively. Compound 8 gave two products 14 and 15 (14/15 4:5), which were generated by the normal and the unusual polycyclization pathways through a chair-chair-boat-chair conformation, respectively. It is remarkable that the twist-boat structure for the B-ring formation was changed to an energetically favored chair structure for the generation of 15. Surprisingly, 14 and 15 consisted of a novel 6,6,6,6-fused tetracyclic ring system, thus differing from the 6,6,6,5-fused lanosterol skeleton. Together with previous results, we conclude that the methyl-29 group is critical to the correct folding of 1, with lesser contributions from the other branched methyl groups, such as methyl-26, -27, and -28. Furthermore, we demonstrate that the methyl-29 group has a crucial role in the formation of the five-membered D ring of the lanosterol scaffold. Ringing in the changes: The incubation of 1 with porcine-liver cyclase afforded new nortriterpenes 2 and 3 with 6,6,6,6-fused tetracyclic skeletons, which were produced by chair-boat-chair-chair and chair-chair-boat-chair conformations, respectively (see scheme), thus indicating that the 29-methyl group is critical to the correct folding of oxidosqualene and to the formation of the five-membered D ring for lanosterol biosynthesis. Copyright

Substituted imidazoles as dual histamine H1 and H3 agonists or antagonists

The present invention discloses novel substituted imidazole compounds which have dual histamine-H1 and H3 receptor antagonist activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such imidazoles as well as methods of using them to treat allergy, inflammatory and CNS-related diseases and others.