57470-18-5

Upstream product

• 17145-91-4 triethyl 2-ethylphosphonoacetate 
• 103-80-0 phenylacetyl chloride 
• 54110-95-1 [1-(ethoxycarbonyl)propyl]triphenylphosphonium bromide 

Downstream Products

• 1089678-74-9 4-allyl-3-ethyl-1-phenyl-1,2,6-heptatrien-4-ol 
• 1206896-50-5 ethyl 2-ethyl-3-fluoro-4-oxo-4-phenyl-2(E)-butenoate 
• 1206896-60-7 3-ethyl-4-fluoro-5-phenyl-2(5H)-furanone 
• 1227751-48-5 ethyl 2-ethyl-4-phenyl-4-(2,4,6-trimethoxyphenyl)but-2(E)-enoate 
• 1380396-88-2 ethyl (2E)-5-acetyl-2-ethyl-6-oxo-4-phenylhept-2-enoate 
• 1380397-03-4 4-acetyl-3-ethyl-5-methyl-3-(2-oxo-2-phenylethyl)furan-2(3H)-one 
• 1611462-07-7 ethyl 5-(4-chlorophenyl)-3-oxo-4-phenyl-2-ethylpent-4(E)-enoate 
• 1280135-92-3 ethyl 2-ethyl-4-phenyl-4-(1-tosyl-1H-indol-3-yl)but-2(Z)-enoate 
• 60492-51-5 3-ethyl-5-phenylfuran-2(5H)-one 
• 1267984-41-7 4-allyl-3-ethyl-5-phenyl-2(5H)-furanone 

Relevant academic research and scientific papers

Study on the selectivity in the electrophilic monofluorination of 2,3-allenoates with Selectfluor: An efficient synthesis of 4-fluoro-2(5H)-furanones and 3-fluoro-4-oxo-2(E)-alkenoates

Different from the reaction of 2,3-allenoic acids with Selectfluor, 4-fluoro-2(5H)-furanones and (E)-3-fluoro-4-oxo-2-alkenoates were highly selectively generated from 2,4-disubstituted 2,3-allenoates with Selectfluor under different conditions in moderate yields. The reaction of 2, 4, 4-trisubstituted 2,3-allenoates afforded the corresponding 4-fluoro-2(5H)-furanones highly selectively with up to 95% yield under different conditions. The scope of the substrates has been carefully explored. Due to the more readily availability of 2,3-allenoates as compared to 2,3-allenoic acids, new 4-fluoro-2(5H)furanones were prepared. Based on the isolation and characterization of the minor fluorohydroxylation product E-5m, a mechanism has been proposed. The Royal Society of Chemistry 2010.