54117-67-8Relevant academic research and scientific papers
Diversity oriented approach to polycyclic compounds through the diels-alder reaction and the Suzuki coupling
Kotha, Sambasivarao,Misra, Shilpi,Srinivas, Venu
scheme or table, p. 4052 - 4062 (2012/09/07)
A diversity oriented strategy has been demonstrated to deliver small "drug like" molecules using alkylation, Diels-Alder reaction, and Suzuki-Miyaura cross-coupling as key steps. This methodology allows access a wide range of molecules using simple scaffolds such as indanes, tetralins and tetrahydroisoquinolines, which can enhance the chemical space for potential therapeutic molecules.
Structure and Reactivity of Isoannulated Heterocyclic Systems with 4n-? and (4n + 2)-? Electrons, XVIII. - Benzothiophenes with Symmetric Structure: Modified and Optimized Preparations by the S-Oxide Route
Kreher, Richard P.,Kalischko, Juergen
, p. 645 - 654 (2007/10/02)
Benzothiophenes (15) with symmetric structure have been prepared efficiently from 1,3-dihydrobenzothiophene 2-oxides (9) by reaction with aluminium oxide, by O-acylation with trifluoroacetic anhydride, or O-alkylation with methyl trifluoromethanesulfonate.The aromatization of the S-oxides 9 is achieved by O-functionalization, subsequent elimination, and consecutive deprotonation.
Studies on the Chemistry of Isoindoles and Isoindolenines, XXXVII. - Symmetrically Substituted 2-Alkyl-2H-isoindoles
Kreher, Richard P.,Sewarte-Ross, Guenter,Vogt, Guenther
, p. 1719 - 1727 (2007/10/02)
2-Alkyl-Rn-2H-isoindoles (1; Rn = 4,5,6,7-tetramethyl, 4,5,6,7-tetrachloro) have been prepared efficiently by the N-oxide route and characterized by spectroscopic means.
Studies on the Chemistry of Isoindoles and Isoindolenines, XXXI. 4,5,6,7-Tetrachloro-and 4,5,6,7-Tetrabromo-2H-isoindoles
Kreher, Richard P.,Herd, Karl Josef
, p. 1827 - 1832 (2007/10/02)
The crystalline 2H-isoindoles 4b are synthesized starting with substituted 2-methylsulfonyl-2,3-dihydro-1H-isoindoles 3 by base-induced elimination of methanesulfinic acid.Compared with the parent compound, a considerable thermal stabilization and chemical deactivation is caused by the halogen atoms at the carbocyclic system.The spectroscopic properties of the o-quinonoid hetarenes 4b have been investigated.
Isoindolinyl derivatives
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, (2008/06/13)
Esters of lower alkanoic acids substituted at the α-position with isoindoline or tetrahydroisoquinoline, and intermediates therefor, useful as pesticides.
Method for the preparation of bis-(bromomethyl)-tetrachlorobenzenes and their use as flame-proofing agents
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, (2008/06/13)
A process for preparing a bis-(bromomethyl)-tetrachlorobenzene which comprises contacting a bis-(chloromethyl)-tetrachlorobenzene with a bromide of an element of the first to the third group of the Periodic Table, preferably in a solvent of the bis-(chlor
