54118-92-2Relevant academic research and scientific papers
Synthesis and evaluation of nonionic surfactants based on dimethylaminoethylamine: Electrochemical investigation and theoretical modeling as inhibitors during electropolishing in-ortho-phosphoric acid
Taha, Asia A.,Shaban, Samy M.,Fetouh,Taha, Salma T.,Sabet,Kim, Dong-Hwan
, (2021/02/03)
Three non-ionic surfactants had synthesized through one simple direct reaction between N, N-dimethylethylenediamine and three fatty acids: octanoic, palmitic and oleic acid. The chemical structures of the synthesized non-ionic surfactants had been confirmed by FTIR & 1HNMR spectroscopy. The surface and thermodynamic behavior of the surfactant were determined at different temperatures based on surface tension (γ) measurments. The critical micelle concentration (CMC) is dependent on both of the hydrophobic chain length and solution temperature. The change in free energy of micellization (?G°mic) and adsorption (?G°ads) referring that the synthesized surfactants favor adsorption at interfaces than constructing a micelle. The performance of the synthesized surfactants on the dissolution behavior of carbon steel in 8 M H3PO4 acid have been investigated at temperature range 15 to 45 °C via weight loss and polarization measurements. The dissolution rate (limiting current IL) decreases with increasing the surfactants concentrations confirming a mass transport-controlled process and a salt-film mechanism. Polarization curves showed that the prepared surfactants are good anodic inhibitors and the adsorption on the carbon steel surface obeys the Langmuir isotherm. The examining the surface morphology, topography and brightness of the carbon steel in a 8 M H3PO4 containing the synthesized surfactants using scanning electron microscope (SEM), atomic force microscope (AFM) and gloss meter, disclosed the adsorption of the prepared inhibitors surfactant on the steel surface. The data obtained from theoretical calculations support empirical results.
Design, synthesis, antibacterial activity and toxicity of novel quaternary ammonium compounds based on pyridoxine and fatty acids
Agafonova, Mariya N.,Chirkova, Milana N.,Druk, Anastasia Y.,Grishaev, Denis Y.,Kayumov, Airat R.,Kazakova, Renata R.,Krylova, Elena S.,Nikishova, Tatyana V.,Nikitina, Elena V.,Sabirova, Alina E.,Sapozhnikov, Sergey V.,Shtyrlin, Nikita V.,Shtyrlin, Yurii G.
, (2021/01/06)
A diverse series of 43 novel “soft antimicrobials” based on quaternary ammonium pyridoxine derivatives which include six-membered acetals and ketals of pyridoxine bound via cleavable linker moieties (amide, ester) with a fragment of fatty carboxylic acid was designed. Nine compounds exhibited in vitro promising antibacterial activity against Gram-positive and Gram-negative bacterial strains with MIC values comparable with reference antiseptics miramistin, benzalkonium chloride and chlorohexidine. On various clinical isolates, the lead compounds 6i and 12a exhibited antibacterial activity comparable with that of benzalkonium chloride while higher than that of miramistin. Moreover, 6i and 12a were able to kill bacteria embedded into the matrix of mono- and dual species biofilms. The treatment of bacterial cells by either 6i and 12a lead to fast depolarization of the membrane suggesting that the membrane is an apparent molecular target of compounds. 6i and 12a were non mutagenic neither in SOS-chromotest nor in Ames test and non-toxic in vivo at acute oral (LD50 > 2000 mg/kg) and cutaneous administration (LD50 > 2500 mg/kg) on mice. Taken together, our data allow suggesting described active compounds as promising starting point for the new antibacterial agents development.
