5412-14-6

Basic information

• Product Name: 2-[(2-chloroethoxy)methyl]oxirane
• CAS NO: 5412-14-6
• Molecular Formula: C₅H₉ClO₂
• Molecular Weight: 136.5768
• Mol File: 5412-14-6.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 196.4°C at 760 mmHg
• Flash Point: 84.2°C
• Density: 1.176g/cm³
• Vapor Pressure: 0.562mmHg at 25°C
• Refractive Index: 1.452
• CAS DataBase Reference: 2-[(2-chloroethoxy)methyl]oxirane(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(2-chloroethoxy)methyl]oxirane(5412-14-6)
• EPA Substance Registry System: 2-[(2-chloroethoxy)methyl]oxirane(5412-14-6)

Safety Data

• Hazardous Substances Data: 5412-14-6(Hazardous Substances Data)

Usage

Physical state

Colorless liquid

Odor

Mild, ether-like

Uses

Chemical intermediate in the production of resins, plastics, and adhesives; stabilizer in the production of PVC and chlorinated rubber; solvent for various applications in chemical synthesis

Hazard class

Moderately hazardous

Safety precautions

Appropriate safety precautions should be taken when handling and storing.

Upstream product

• 35982-12-8 3-(2-chloroethoxy)-1,2-propanediol 
• 106-89-8 epichlorohydrin 
• 107-07-3 2-chloro-ethanol 
• 27905-76-6 2-(2-chloroethoxy)-3-chloropropan-2-ol 

Downstream Products

• 56217-56-2 1,4-dioxane-2-carbaldehyde 
• 250340-68-2 1-(2-chloroethoxy)-2-tosyl-3-azidopropane 
• 250340-69-3 1-(2-chloroethoxy)-2-tosyl-3-methoxypropane 
• 21048-16-8 2-(chloromethyl)-1,4-dioxane 
• 29908-11-0 (+/-)-2-(hydroxymethyl)-1,4-dioxane 

Relevant articles and documents

Synthesis and thermal properties of poly(2-chloroethyl glycidyl ether)-based side-chain liquid-crystalline polymers

A novel series of poly(2-chloroethyl glycidyl ether)-based side-chain liquid-crystalline copolymers has been synthesized in which the mesogenic units are biphenyl 4-methoxybiphenyl, 4-methoxyazobenzene, and N-benzylidene-4- methoxyaniline, respectively (corresponding polymers are referred to as PCBH, PCMB, PCMA, and PCBM). The structures of the compounds obtained are characterized by infrared (IR) and 1H nuclear magnetic resonance (NMR). The thermal properties were investigated using polarized optical microscopy, differential scanning calorimetry, and X-ray diffraction analysis. The results indicate that PCMA, PCMB, and PCBM exhibit thermotropic liquid-crystalline behavior and present nematic phases with Schlieren textures. However, PCBH does not display a mesogenic phase. The decomposition temperatures of copolymers begin at 290°C. Copyright Taylor & Francis Group, LLC.

Self-neutralizing oligonucleotides with enhanced cellular uptake

There is tremendous potential for oligonucleotide (ON) therapeutics, but low cellular penetration due to their polyanionic nature is a major obstacle. We addressed this problem by developing a new approach for ON charge neutralization in which multiple branched charge-neutralizing sleeves (BCNSs) are attached to the internucleoside phosphates of ON by phosphotriester bonds. The BCNSs are terminated with positively charged amino groups, and are optimized to form ion pairs with the neighboring phosphate groups. The new modified ONs can be prepared by standard automated phosphoramidite chemistry in good yield and purity. They possess good solubility and hybridization properties, are not involved in non-standard intramolecular aggregation, have low cytotoxicity, adequate chemical stability, improved serum stability, and above all, display significantly enhanced cellular uptake. Thus, the new ON derivatives exhibit properties that make them promising candidates for the development of novel therapeutics or research tools for modulation of the expression of target genes.

Synthesis of N-3-chloroalkoxy-2-nitroxypropyl-N-alkylnitramines and their subsequent azidation

Nitration of N-3-chloroalkoxy-2-hydroxypropyl-N-alkylsulfamates gave the corresponding N-3-chloroalkoxy-2-nitroxypropyl-N-alkylnitramines. Azidation of the latter resulted in N-azido-3-azidoalkoxypropyl-N-alkylnitramines.