29908-11-0

Basic information

• Product Name: 1,4-DIOXANE, 2-(HYDROXYMETHYL)-
• Synonyms: 1,4-DIOXANE, 2-(HYDROXYMETHYL)-;1,4-Dioxan-2-ylmethanol;1,4-dioxan-2-ylmethanol(SALTDATA: FREE);2-Methanol-1,4-dioxane;1,4-Dioxane-2-methanol;1,2-Ethylideneglycerol;2-(Hydroxymethyl)-1,4-dioxane;p-Dioxanemethanol
• CAS NO: 29908-11-0
• Molecular Formula: C₅H₁₀O₃
• Molecular Weight: 118.1311
• Mol File: 29908-11-0.mol

Chemical Properties

• Boiling Point: 208.2 °C at 760 mmHg
• Flash Point: 96.3 °C
• Appearance: /
• Density: 1.102 g/cm³
• Vapor Pressure: 0.0503mmHg at 25°C
• Refractive Index: 1.433
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 14.24±0.10(Predicted)
• CAS DataBase Reference: 1,4-DIOXANE, 2-(HYDROXYMETHYL)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-DIOXANE, 2-(HYDROXYMETHYL)-(29908-11-0)
• EPA Substance Registry System: 1,4-DIOXANE, 2-(HYDROXYMETHYL)-(29908-11-0)

Safety Data

• Hazardous Substances Data: 29908-11-0(Hazardous Substances Data)

Usage

Uses

Used in Chemical Synthesis:
1,4-DIOXANE, 2-(HYDROXYMETHYL)is used as a synthetic intermediate for the production of various chemicals and pharmaceuticals. Its hydroxymethyl group allows for further functionalization and modification, making it a valuable building block in the synthesis of complex molecules.
Used in Solvent Applications:
In the chemical industry, 1,4-DIOXANE, 2-(HYDROXYMETHYL)is used as a solvent for a wide range of substances. Its ability to dissolve both polar and nonpolar compounds makes it a versatile choice for various chemical processes and reactions.
Used in Laboratory Research:
Due to its stability and reactivity, 1,4-DIOXANE, 2-(HYDROXYMETHYL)is often employed in laboratory research as a reactant or a solvent. It is particularly useful in the synthesis of new compounds and the study of chemical reactions.
Used in the Pharmaceutical Industry:
1,4-DIOXANE, 2-(HYDROXYMETHYL)is used as a key component in the development of new drugs and pharmaceuticals. Its unique structure and properties make it an attractive candidate for the design of novel therapeutic agents.
Used in the Production of Polymers:
In the polymer industry, 1,4-DIOXANE, 2-(HYDROXYMETHYL)is used as a monomer in the synthesis of various types of polymers. Its ability to form covalent bonds with other monomers allows for the creation of polymers with specific properties and applications.
Used in the Cosmetics Industry:
1,4-DIOXANE, 2-(HYDROXYMETHYL)is also utilized in the cosmetics industry, where it serves as a component in the formulation of various personal care products. Its compatibility with a wide range of ingredients makes it a valuable addition to cosmetic formulations.

InChI:InChI=1/C5H10O3/c6-3-5-4-7-1-2-8-5/h5-6H,1-4H2

Upstream product

• 143669-40-3 (+/-)-3,6,8-trioxabicyclo<3.2.1>octane 
• 16801-25-5 1-(2-hydroxyethoxy)-2,3-epoxypropane 
• 7664-93-9 sulfuric acid 
• 5412-14-6 3-(β-Chloroethoxy)-1,2-epoxypropane 
• 35982-12-8 3-(2-chloroethoxy)-1,2-propanediol 
• 68391-40-2 acetoxymethyl-[1,4]dioxane 
• 92905-04-9 (+/-)-4-<(benzyloxy)methyl>-2-(bromomethyl)-1,3-dioxolane 
• 87179-37-1 (+/-)-2-(bromomethyl)-4-(hydroxymethyl)-1,3-dioxalane 
• 27905-76-6 2-(2-chloroethoxy)-3-chloropropan-2-ol 
• 18371-74-9 1-chloro-3-(2-hydroxyethoxy)-2-propanol 
• 99777-55-6 ethyl 2-(1,4-dioxan-2-ylmethoxy)crotonate 

Downstream Products

• 406913-84-6 2-hydroxymethyl-1,4-dioxane hydrogen phthalate 
• 56217-56-2 1,4-dioxane-2-carbaldehyde 
• 6249-69-0 1-(1,4-dioxan-2-yl)-N,N,N-trimethylmethanaminium iodide 
• 1512718-16-9 (1,4-dioxan-2-yl)methyl 4-methylbenzenesulfonate 
• 913696-60-3 4-(1,4-dioxan-2-ylmethoxy)-2,3-dimethylpyridine 1-oxide 
• 406913-89-1 Phthalic acid mono-(R)-1-[1,4]dioxan-2-ylmethyl ester 
• 406913-91-5 Phthalic acid mono-(S)-1-[1,4]dioxan-2-ylmethyl ester 
• 406913-93-7 [(2S)-1,4-dioxan-2-yl]methanol 
• 406913-88-0 (R)-(-)-2-hydroxymethyl-1,4-dioxane 
• 21048-16-8 2-(chloromethyl)-1,4-dioxane 

Relevant articles and documents

Meso-Tetra(dioxanyl)porphyrins: Neutral, low molecular weight, and chiral porphyrins with solubility in aqueous solutions

The synthesis of the low-molecular weight, meso-Tetra(dioxan-2-yl)porphyrin with considerable solubility in aqueous solution is described. The key intermediate dioxan-2-carbaldehyde is accessible in either racemic or in stereo-pure forms from commercially available starting materials in three steps. Using 4 × 1 or 2 + 2-Type syntheses provide the porphyrin in modest yields. While the racemic aldehyde created an intractable mixture of diastereomers, the enantiopure aldehyde created a single enantiomer of the target porphyrin. The porphyrin was spectroscopically characterized. As its free base or zinc complex, it showed excellent solubility properties in organic and aqueous solvents, though free water-solubility was not achieved. The work expands on the availability of chiral porphyrins and neutral porphyrins with considerable solubility in aqueous solution.

Benzimidazole compound

An object of the present invention is to provide a novel chemical compound useful as a therapeutic or prophylactic agent for acid-related diseases, having an excellent inhibitory effect against gastric acid secretion, an excellent effect of maintaining the inhibitory effect against gastric acid secretion, thereby maintaining intragastric pH high for a long time, and having more safety and appropriate physicochemical stability. Provided is a compound represented by where R1 and R3 may be the same or different and each represent a hydrogen atom or a C1-C6 alkyl group; R2 represents (5,5-dimethyl-1,3-dioxan-2-yl)methoxy group, 5,7-dioxaspiro[2.5]oct-6-ylmethoxy group, 1,5,9-trioxaspiro[5.5]undec-3-ylmethoxy group, or (2,2-dimethyl-1,3-dioxan-5-yl)methoxy group; R4, R5, R6 and R7 represent a hydrogen atom, halogen atom, C1-C6 alkyl group, C1-C6 haloalkyl group, C1-C6 alkoxy group or C1-C6 haloalkoxy group; and W1 represents a single bond, methylene or ethylene group, a salt thereof or a solvate of these.

2-Hydroxymethyl-1,4-dioxane: Synthesis, resolution and determination of the absolute configurations of the enantiomers

2-Hydroxymethyl-1, 4-dioxane 3 was resolved via salt formation between its hydrogen phthalate and (R)- or (S)-1-phenylethylamine, selective crystallization of the resultant diastereomeric mixtures and subsequent recovery of its enantiomers by saponification. The progress of the resolution was followed by chiral HPLC and the absolute stereochemistry of the two enantiomers determined by comparison of their specific rotations with that of (R)-3 synthesized from enantiomerically pure (R)-1-O-benzylglycerol. The results of the synthesis of 3 and of its resolution are discussed and compared with those previously obtained for 1,2-isopropylidene glycerol evaluating the consequences of replacement of ispropylidene with an ethylene bridge.

Syntheses of All Four Stereoisomers Which Are Conformationally Constrained 1,4-Dioxanyl Analogs of the Antineoplastic Ether Lipid ET-18-OCH3

The syntheses of each of the four nearly optically pure stereoisomers of oxy>phosphocholine (2,3,2',3') were performed by two parallel divergent sequences.Phosphocholines 2 and 3 were prepared via the corresponding 5-heptadecyl-2-(hydroxymethyl)-1,4-dioxanes 21 and 23, respectively, from the completely regiospecific mixed-hydride reductions of (1R,4S,5S)-4-heptadecyl-3,6,8-trioxabicyclooctane (19) and (1R,4R,5S)-4-heptadecyl-3,6,8-trioxabicyclooctane (20), respectively.The two 4-heptadecyl-3,6,8-trioxabicyclooctanes 19 and 20 were the two separable products from an intramolecular cyclization reaction.By a parallel divergent sequence from the enantiomeric starting material, 3-O-benzyl-sn-glycerol (16'), the other two diastereomeric oxy>phosphocholines 2' and 3' were prepared.These four monocyclic oxy>phosphocholines (2,3,2',3') are conformationally constrained analogs of the antineoplastic and immunomodulatory ether lipid rac-2-O-methyl-1-O-octadecylglycero-3-phosphocholine (rac-1) (rac-ET-18-OCH3, rac-Edelfosine).

Alkylation of active methylene compounds with 2-chloromethyl-1,4-dioxane

The alkylation of some active methylene compounds with 2-chloromethyl-1,4-dioxane was investigated.It was shown that malonic ester gives mono- and dialkylation products, depending on the conditions.The alkylation of acetoacetic ester gives a mixture of C- and O-alkylation products.Acetylacetone is not alkylated under the given conditions but condenses fully, being converted into 2,4-dimethyl-6-hydroxyacetophenone.