54123-08-9

Upstream product

• 30199-04-3 2,3-dihydro-5-phenyl-1H-thieno[2,3-e]-1,4-diazepin-2-one 

Downstream Products

• 58066-31-2 6H-thieno-<3,2-f><1,2,4>triazolo<4,3-a><1,4>diazepine 
• 54123-09-0 9-methyl-4-phenyl-6H-thieno[3,2-f]-s-triazolo[4,3-a][1,4]diazepine 
• 54123-10-3 5-phenyl-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one acetylhydrazone 

Relevant academic research and scientific papers

Thienotriazolodiazepine derivatives

Novel thienotriazolodiazepine derivatives and processes for their preparation are described. These compounds are useful as anticonvulsants, muscle-relaxants and sedatives.

Syntheses and structure-activity relationships of 6-Aryl-4H-s-triazolo[3,4-c]thieno[2,3-e][1,4]diazepines

A variety of 6 aryl 4H s triazolo [3,4-c]thieno [2,3-e] [1,4]diazepines was synthesized and tested for anti-pentylenetetrazole activity and inhibition of fighting episodes. The structure-activity relationships are discussed. Some compounds were more active than diazepam in the two assays. Among them, 6 (o chlorophenyl) 8 ethyl 1 methyl 4H s triazolo [3,4-c] thieno [2,3-e][1,4] diazepine was found to have favourable properties as an anxiolytic drug with very low toxicity. Clinical studies of this compound (Y-7131) are under way.