5413-96-7

Usage

Uses

Used in Pharmaceutical Industry:
4-Chloro-1,6-dimethyl-1H-pyrazolo[3,4-d]pyrimidine is utilized as a key intermediate in the development of new drugs for various medical treatments. Its unique structure and properties make it a promising candidate for the creation of innovative therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical sector, 4-chloro-1,6-dimethyl-1H-pyrazolo[3,4-d]pyrimidine is employed as a component in the formulation of pesticides, fungicides, and herbicides. Its incorporation enhances the effectiveness of these products, contributing to improved crop protection and yield.
Used in Research and Development:
4-Chloro-1,6-dimethyl-1H-pyrazolo[3,4-d]pyrimidine is a compound of significant interest to researchers and scientists in the fields of chemistry, pharmacology, and agriculture. Its versatility and potential applications make it a valuable subject for ongoing studies aimed at uncovering new uses and refining existing ones.

InChI:InChI=1/C6H6ClN5/c1-12-5-3(2-9-12)4(8)10-6(7)11-5/h2H,1H3,(H2,8,10,11)

Upstream product

• 98141-42-5 4,6-dichloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine 
• 50270-27-4 2,4,6-trichloropyrimidine-5-carbaldehyde 
• 5334-41-8 5-amino-4-cyano-1-methylpyrazole 
• 5401-15-0 1-Methyl-1H-pyrazolo<3,4-d>pyrimidine-4,6(5H,7H)-dione 

Downstream Products

• 5444-33-7 2-(4-amino-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino)-ethanol 
• 5399-91-7 6-amino-1-methyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one 
• 91843-67-3 1-methyl-6-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine 

Relevant academic research and scientific papers

PYRIMIDINE AMIDE COMPOUNDS AND USE THEREOF

Disclosed are compounds of formula (I) below or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof: (I), in which each of variables each of variables R, R1, R2, X1, X2, X3 and n is defined herein. Also disclosed is a method for treating a cancer with a compound of formula (I) or a salt thereof and a pharmaceutical composition containing same.

Discovery of dual orexin receptor antagonists with rat sleep efficacy enabled by expansion of the acetonitrile-assisted/diphosgene-mediated 2,4-dichloropyrimidine synthesis

Recent clinical studies have demonstrated that dual orexin receptor antagonists (OX1R and OX2R antagonists or DORAs) represent a novel treatment option for insomnia patients. Previously we have disclosed several compounds in the diazepane amide DORA series with excellent potency and both preclinical and clinical sleep efficacy. Additional SAR studies in this series were enabled by the expansion of the acetonitrile-assisted, diphosgene-mediated 2,4-dichloropyrimidine synthesis to novel substrates providing an array of Western heterocycles. These heterocycles were utilized to synthesize analogs in short order with high levels of potency on orexin 1 and orexin 2 receptors as well as in vivo sleep efficacy in the rat.

2-PYRIDYL CARBOXAMIDE-CONTAINING SPLEEN TYROSINE KINASE (SYK) INHIBITORS

The invention provides certain 2-pyridyl carboxamide-containing compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein A and B are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk) kinase.