98141-42-5

Basic information

• Product Name: 4,6-dichloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine
• Synonyms: 4,6-dichloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine;4,6-Dichloro-1-Methyl-1H-...;1H-Pyrazolo[3,4-d]pyriMidine, 4,6-dichloro-1-Methyl-
• CAS NO: 98141-42-5
• Molecular Formula: C₆H₄Cl₂N₄
• Molecular Weight: 203.02876
• Product Categories: Building Blocks;Pyrazolo[x,x-y]pyridine
• Mol File: 98141-42-5.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 284℃
• Flash Point: 125℃
• Appearance: /
• Density: 1.76
• Vapor Pressure: 0.00528mmHg at 25°C
• Refractive Index: 1.76
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -0.19±0.10(Predicted)
• CAS DataBase Reference: 4,6-dichloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6-dichloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine(98141-42-5)
• EPA Substance Registry System: 4,6-dichloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine(98141-42-5)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• RIDADR: UN2811
• Hazardous Substances Data: 98141-42-5(Hazardous Substances Data)

Usage

General Description

4,6-dichloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine is a chemical compound with the molecular formula C7H5Cl2N3. It is a heterocyclic compound with potential biological and pharmaceutical applications. 4,6-dichloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine has a pyrazolo[3,4-d]pyrimidine core and is substituted with a methyl group and two chlorine atoms at the 1, 3, and 6 positions, respectively. It exhibits potential antitumor and antiviral activities and has been studied for its potential use in cancer treatment. Additionally, it has shown inhibitory effects on a variety of protein kinases, making it a potential candidate for the development of kinase inhibitors in drug discovery.

InChI:InChI=1/C6H4Cl2N4/c1-12-5-3(2-9-12)4(7)10-6(8)11-5/h2H,1H3

Upstream product

• 7339-53-9 methyl hydrazine hydrochloride 
• 50270-27-4 2,4,6-trichloropyrimidine-5-carbaldehyde 
• 302-15-8 methylhydrazine sulfuric acid 
• 42754-96-1 4,6-dichloro-1H-pyrazolo[3,4-d]pyrimidine 
• 74-88-4 methyl iodide 
• 5334-41-8 5-amino-4-cyano-1-methylpyrazole 
• 503-38-8 trichloromethyl chloroformate 
• 60-34-4 methylhydrazine 
• 5401-15-0 1-Methyl-1H-pyrazolo<3,4-d>pyrimidine-4,6(5H,7H)-dione 

Downstream Products

• 5413-96-7 6-chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine 
• 1607479-47-9 C₂₂H₂₅N₉O 
• 5326-77-2 (6-chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-methyl-amine 
• 122568-11-0 N⁴,N⁶-bis-(2,4-dimethyl-phenyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidine-4,6-diyldiamine 
• 30682-70-3 1-methylpyrazolo[3,4-d]pyrimidin-4,6(5H,7H)-dithione 
• 109042-48-0 ethyl-(6-chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-phenyl-amine 

Relevant articles and documents

PYRIMIDINE AMIDE COMPOUNDS AND USE THEREOF

Disclosed are compounds of formula (I) below or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof: (I), in which each of variables each of variables R, R1, R2, X1, X2, X3 and n is defined herein. Also disclosed is a method for treating a cancer with a compound of formula (I) or a salt thereof and a pharmaceutical composition containing same.

SUBSTITUTED PENTA-FUSED HEXA-HETEROCYCLIC COMPOUNDS, PREPARATION METHOD THEREFOR, DRUG COMBINATION AND USE THEREOF

A type of substituted penta-fused hexa-heterocyclic compounds having selective inhibition for PIKfyve kinase, a pharmaceutically acceptable salt and pharmaceutically acceptable solvate thereof, a method for the preparation thereof, a pharmaceutical composition comprising the same, and use of these compounds in the manufacture of a medicament for preventing or treating a disease associated with PIKfyve in vivo, in particular in the manufacture of a medicament for preventing or treating tumor growth and metastasis.

INHIBITORS OF INFLUENZA VIRUS REPLICATION, APPLICATION METHODS AND USES THEREOF

The invention provides a novel class of compounds as inhibitors of influenza virus replication, preparation methods thereof, pharmaceutical compositions containing these compounds, and uses of these compounds and pharmaceutical compositions thereof in the treatment of influenza.