54136-23-1

Basic information

• Product Name: 5-fluoro-2,3,3-triMethyl-3H-Indole
• Synonyms: 5-fluoro-2,3,3-triMethyl-3H-Indole
• CAS NO: 54136-23-1
• Molecular Formula: C₁₁H₁₂FN
• Molecular Weight: 177.2180832
• Mol File: 54136-23-1.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 235℃
• Flash Point: 96℃
• Appearance: /
• Density: 1.08
• PKA: 5.38±0.40(Predicted)
• CAS DataBase Reference: 5-fluoro-2,3,3-triMethyl-3H-Indole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-fluoro-2,3,3-triMethyl-3H-Indole(54136-23-1)
• EPA Substance Registry System: 5-fluoro-2,3,3-triMethyl-3H-Indole(54136-23-1)

Safety Data

• Hazardous Substances Data: 54136-23-1(Hazardous Substances Data)

Upstream product

• 563-80-4 3-methyl-butan-2-one 
• 371-40-4 4-fluoroaniline 
• 371-14-2 4-fluorophenylhydrazine 
• 823-85-8 4-fluorophenyhydrazine hydrochloride 

Downstream Products

• 1261138-47-9 C₂₀H₂₁FN₂ 
• 1261138-49-1 C₂₁H₂₄FN₂⁽¹⁺⁾*I^(1-) 

Relevant articles and documents

Synthesis and Characterization of Novel Pyrazole Derivatives from 4-Florophenylhydrazine and Study Their Cytotoxicity as Anti-Cancer Agent

Series of new pyrazole derivatives have been successfully synthesized, their purity confirmed by thin-layer chromatography and the chemical structures identified by some spectroscopic techniques like 1H-NMR, APT 13C-NMR and FT-IR. Two synthetic precursors

Ultrabright and Serum-Stable Squaraine Dyes

Highly stable symmetric and asymmetric squaraine fluorophores have been synthesized featuring an internal salt bridge between a quaternary ammonium cation and the central oxycyclobutenolate ring of the chromophore. Some of our newly synthesized symmetric and asymmetric compounds display increased molar absorptivity, quantum yield in serum, and thermal/photochemical stability over previously reported squaraine-based dyes. Consequently, both classes show great promise in resurfacing the normal environment-labile squaraine dyes as novel imaging agents and scaffolds for fluorescence sensing. Furthermore, incorporating a covalent attachment point away from the conjugated system allows for biological tagging applications without disturbing the optimum optical characteristics of the newly designed fluorophore.

Effects of Substituents on Metastable-State Photoacids: Design, Synthesis, and Evaluation of their Photochemical Properties

Recently, metastable-state photoacids have been widely used to control proton transfer in numerous chemical and biological processes as well as applications with visible light. Generally, substituents have a great influence on the photochemical properties of molecules, which will further affect their applications. Yet, the effects of substituents on metastable-state photoacids have not been studied systematically. In this work, 16 metastable-state photoacid derivatives were designed and synthesized on the basis of substituents having a large range of σ–π electron–donor–acceptor capabilities. The effects of substituents on the color display [or maximum absorption band(s)], solubility, pKa values, dark/photoacidity, photosensitivity, and relaxation kinetic(s) were investigated in detail. This study will be helpful for the targeted design and synthesis of promising photoacids and the application of their photocontrolled proton-release processes in functional materials/devices.