5415-74-7Relevant academic research and scientific papers
Synthesis of new vulcan-shape aromatic polyimides for IPS-mode and their alignment properties
Son, Kyung-Chul,Park, Dong-Ju,Kim, Yong-Bae,Park, Jae-Cheol
, p. 81 - 93 (2007)
In plane switching (IPS)-mode liquid crystal display (LCD) is one of the most useful technologies for a wide range of viewing angles. For IPS-mode application, we synthesized novel diamine containing a methyl group as a bridge and homogeneous alignment ma
Doing the methylene shuffle - Further insights into the inhibition of mitotic kinesin Eg5 with S-trityl l-cysteine
Abualhasan, Murad N.,Good, James A.D.,Wittayanarakul, Kitiyaporn,Anthony, Nahoum G.,Berretta, Giacomo,Rath, Oliver,Kozielski, Frank,Sutcliffe, Oliver B.,MacKay, Simon P.
experimental part, p. 483 - 498 (2012/09/10)
S-Trityl l-cysteine (STLC) is an inhibitor of the mitotic kinesin Eg5 with potential as an antimitotic chemotherapeutic agent. We previously reported the crystal structure of the ligand-protein complex, and now for the first time, have quantified the interactions using a molecular dynamics based approach. Based on these data, we have explored the SAR of the trityl head group using the methylene shuffle strategy to expand the occupation of one of the hydrophobic pockets. The most potent compounds exhibit strong (100 nM) inhibition of Eg5 in the basal ATPase assay and inhibit growth in a variety of tumour-derived cell lines.
Palladium-catalysed direct synthesis of benzo[b]thiophenes from thioenols
Inamoto, Kiyofumi,Arai, Yukari,Hiroya, Kou,Doi, Takayuki
supporting information; experimental part, p. 5529 - 5531 (2009/04/13)
The one-pot conversion of thioenols into benzo[b]thiophenes was achieved by using a simple palladium catalyst such as PdCl2 or PdCl 2(cod). The Royal Society of Chemistry.
