54150-53-7

Upstream product

• 637-51-4 isothiocyanatobenzene 
• 74-88-4 methyl iodide 

Downstream Products

• 37546-64-8 trans-1-phenyl-3-(p-tosyloxy)-4-(methylthio)-2-azetidinone 
• 72726-88-6 3-(N-Phenyl-formimidoylsulfanyl)-propionic acid methyl ester 
• 73025-57-7 (Z)-2-Anilino-1-nitro-1-phenylethene 
• 109900-98-3 ((Z)-2-Nitro-propenyl)-phenyl-amine 
• 125828-51-5 cis-1-Phenyl-3-(tosyloxy)-4-chloro-2-azetidinone 
• 125828-51-5 trans-1-Phenyl-3-(tosyloxy)-4-chloro-2-azetidinone 
• 72726-89-7 4-(2-Methoxycarbonylethylthio)-1,3,3-triphenyl-2-azetidinone 

Relevant academic research and scientific papers

Synthesis of 4-Thioxo-2-azetidinones

4-Thioxo-2-azetidinones, which are C- and N-substituted imides of monothionomalonic acid, have been prepared by a thermal rearrangement of 4-(2-methoxycarbonylethylsulfinyl)-2-azetidinones through the intermediacy of β-lactam 4-sulfenic acids.The 4-sulfinyl-2-azetidinones have been obtained by total synthesis, or from penicillin sulfoxides.The former approach, which allows the choice of variegated arrays of substituents, was employed in the synthesis of (+/-)-1-(1-methoxycarbonyl)-2-methylprop-1-enyl)-3-phthalimido-4-thioxo-2-azetidinone (8) (a didehydrovaline derivative), (+/-)-1-(1-(tert-butoxycarbonyl)-2-tert-butoxyethyl)-3- phthalimido-4-thioxo-2-azetidinone (19) (a serine derivative), and 1,3,3-triphenyl-4-thioxo-2-azetidinone (20).Compound 27, which is the levorotatory enantiomer of the racemic 8, has been obtained by the degradation of methyl 6-(β-phthalimido)penicillanate sulfoxide (21).