541539-88-2Relevant academic research and scientific papers
Unparalleled Ease of Access to a Library of Biheteroaryl Fluorophores via Oxidative Cross-Coupling Reactions: Discovery of Photostable NIR Probe for Mitochondria
Cheng, Yangyang,Li, Gaocan,Liu, Yang,Shi, Yang,Gao, Ge,Wu, Di,Lan, Jingbo,You, Jingsong
, p. 4730 - 4738 (2016)
The development of straightforward accesses to organic functional materials through C-H activation is a revolutionary trend in organic synthesis. In this article, we propose a concise strategy to construct a large library of donor-acceptor-type biheteroar
Direct N-Alkylation and Kemp Elimination Reactions of 1-Sulfonyl-1H-Indazoles
Tang, Meng,Chu, Bingjie,Chang, Xiaowei
, p. 2109 - 2116 (2018/07/31)
The reactions of 1-sulfonyl-1H-indazoles under basic conditions are discussed, and the direct N-alkylation and Kemp elimination reactions of these compounds are reported. A series of 2-(p-tosylamino)benzonitriles and N-alkyl indazoles were prepared in good yields. Moreover, the 2-(p-tosylamino)benzonitriles could be transformed into a diverse range of important derivatives in a one-pot reaction. This method was successfully applied to the total syntheses of quindolinone and cryptolepinone; quindolinone was prepared in a one-pot reaction from 1-sulfonyl-1H-indazole.
HISTONE DEMETHYLASE INHIBITORS
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Paragraph 00116, (2016/04/20)
The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted pyrrolopyridine derivative compounds and pharmaceutical compositions comprising said compounds. The subject com
Regioselective methylation of indazoles using methyl 2,2,2- trichloromethylacetimidate
Baddam, Sudhakar Reddy,Uday Kumar,Panasa Reddy,Bandichhor, Rakeshwar
supporting information, p. 1661 - 1663 (2013/03/29)
An efficient and regio selective synthesis of substituted 2-methyl-2H-indazoles using a methyl 2,2,2-trichloroacetimidate is described.
HETEROCYCLIC COMPOUNDS AS AGONISTS FOR THE THYROID RECEPTOR
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Page/Page column 69-72, (2010/11/25)
The invention provides Compounds of formula (I) or pharmaceutically acceptable esters, amides, solvates or salts thereof, including salts of such esters or amides, and solvates of such esters, amides or salts, wherein R3, R4, G, Y, W and R5 are as defined in the specification. The invention also provides the use of such Compounds in the treatment or Prophylaxis of a condition associated with a disease or disorder associated with thyroid receptor activity.
Efficient and regioselective synthesis of 2-alkyl-2H-indazoles
Cheung, Mui,Boloor, Amogh,Stafford, Jeffrey A.
, p. 4093 - 4095 (2007/10/03)
An efficient and regioselective synthesis of 2-methyl-2H-indazoles and 2-ethyl-2H-indazoles using trimethyloxonium tetrafluoroborate or triethyloxonium hexafluorophosphate is reported.
