5417-73-2Relevant academic research and scientific papers
Synthesis of N-substituted aryl amidines by strong base activation of amines
Khalifa, Muhammad M.,Bodner, Micah J.,Berglund, J. Andrew,Haley, Michael M.
supporting information, p. 4109 - 4111 (2015/08/03)
Abstract We describe an efficient method for the direct preparation of N-substituted aryl amidines from nitriles and primary amines. The protocol employs activation of amines by a strong base and provides greater access to a pharmaceutically relevant functional group. This synthetic approach tolerates deactivated nitriles, nitriles with competing substitution sites, and aryl amines.
