5417-86-7

Usage

Uses

Used in Pharmaceutical Industry:
6-N-PROPOXYPURINE is used as a therapeutic agent for the treatment of cognitive impairment and neurodegenerative disorders due to its ability to act as an adenosine receptor antagonist, which may improve cognitive function and potentially slow the progression of these conditions.
Used in Research and Development:
6-N-PROPOXYPURINE is used as a research compound for studying the mechanisms of cognitive impairment and neurodegeneration, as well as for exploring its potential as a therapeutic agent for conditions such as Alzheimer's disease and Parkinson's disease. Further research is needed to determine its efficacy and safety in humans.

InChI:InChI=1/C8H10N4O/c1-2-3-13-8-6-7(10-4-9-6)11-5-12-8/h4-6H,2-3H2,1H3

Upstream product

• 71-23-8 propan-1-ol 
• 87-42-3 6-chloropurine 
• 146331-47-7 NU₂₀₁₃ 

Relevant academic research and scientific papers

Simple, chemoselective hydrogenation with thermodynamic stereocontrol

Few methods permit the hydrogenation of alkenes to a thermodynamically favored configuration when steric effects dictate the alternative trajectory of hydrogen delivery. Dissolving metal reduction achieves this control, but with extremely low functional group tolerance. Here we demonstrate a catalytic hydrogenation of alkenes that affords the thermodynamic alkane products with remarkably broad functional group compatibility and rapid reaction rates at standard temperature and pressure.

N7-DNA: Base-pairing properties of N7-(2'-deoxy-β-d-erythro- pentofuranosyl)-substituted adenine, hypoxanthine, and guanine in duplexes with parallel chain orientation

Oligonucleotides containing N7-(2'-deoxy-β-D-erythro- pentofuranosyl)adenine (1), -hypoxanthine (2), and -guanine (3) were synthesized on solid-phase using phosphonate and phosphoramidite chemistry. As part of the synthesis of compound 2, the nucleobase-anion glycosylation of various 6-alkoxypurines with 2-deoxy-3,5-di-O-(4-toluoyl)-α-D-erythro- pentofuranosyl chloride (5) was investigated. The duplex stability of oligonucleotides containing N7-glycosylated purines opposite to regular pyrimidines was determined, and thermodynamic data were calculated from melting profiles. Oligodeoxyribonucleotide duplexes containing N7- glycosylated adenine. T(d) or N7-glycosylated guanine C(d) base pairs are more stable in the case of parallel strand orientation than in the case of antiparallel chains.