54176-51-1Relevant articles and documents
WDR5 INHIBITORS AND MODULATORS
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Paragraph 00135, (2020/12/29)
Quinazolin-4(3H)-one, 2,3 -dihydroquinazolin-4(1H)-one, 3,4-dihydrobenzo[f][1,4]oxazepin- 5(2H)-one, and 3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione compounds and derivatives inhibit WDR5 and associated protein-protein interactions, and the compounds and their pharmaceutical compositions are useful for treating disorders and conditions in a subject, such as cancer cell proliferation.
COMPOUNDS CONTAINING FUSED RINGS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF
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, (2011/11/01)
The invention provides novel beta-secretase inhibitors and methods for their use, including methods of treating Alzheimer's disease.