636-46-4

Basic information

• Product Name: 4-Hydroxyisophthalic acid
• Synonyms: HYDROXYISOPHTHALIC ACID, 4-;4-HYDROXYISOPHTHALIC ACID;4-HYDROXYBENZENE-1,3-DICARBOXYLIC ACID;4-HYDROXY-1,3-BENZENEDECARBOXYLIC ACID;4-HYDROXY-1,3-BENZENEDICARBOXYLIC ACID;ACETYLSALISYLIC ACID IMP B;4-hipa;4-hydroxy-3-benzenedicarboxylicacid
• CAS NO: 636-46-4
• Molecular Formula: C₈H₆O₅
• Molecular Weight: 182.13
• EINECS: 211-258-0
• Product Categories: Phthalic Acids, Esters and Derivatives;API intermediates;Aromatics;Impurities;Aromatics, Impurities
• Mol File: 636-46-4.mol
• Article Data: 16

Chemical Properties

• Melting Point: >300°C
• Boiling Point: 310 C
• Flash Point: 238.6 °C
• Appearance: White powder
• Density: 1.4411 (rough estimate)
• Vapor Pressure: 8.58E-09mmHg at 25°C
• Refractive Index: 1.5690 (estimate)
• Storage Temp.: 2-8°C
• Solubility: DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
• PKA: 2?+-.0.10(Predicted)
• Water Solubility: 0.3g/L(24 oC)
• Merck: 14,4827
• CAS DataBase Reference: 4-Hydroxyisophthalic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Hydroxyisophthalic acid(636-46-4)
• EPA Substance Registry System: 4-Hydroxyisophthalic acid(636-46-4)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-41-22-36/38
• Safety Statements: 26-36/37/39-36-39-6
• WGK Germany: 3
• RTECS: NT2544000
• Hazardous Substances Data: 636-46-4(Hazardous Substances Data)

Usage

Chemical Properties

White powder

Uses

Different sources of media describe the Uses of 636-46-4 differently. You can refer to the following data:
1. 4-Hydroxyisophthalic acid has been proposed as an improvement over aspirin. An impurity of Acetylsalicylic acid (A187780).
2. 4-Hydroxyisophthalic acid has been proposed as an improvement over aspirin. An impurity of Acetylsalicylic acid (A187780). Acetylsalicylic Acid Impurity B; Aspirin Impurity B

General Description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

InChI:InChI=1/C8H6O5/c9-6-2-1-4(7(10)11)3-5(6)8(12)13/h1-3,9H,(H,10,11)(H,12,13)/p-2

Upstream product

• 88-61-9 2,4-dimethylbenzenesulfonic acid 
• 584-87-2 3-formyl-4-hydroxybenzoic acid 
• 100-67-4 potassium phenolate 
• 139-02-6 sodium phenoxide 
• 15719-64-9 methylammonium carbonate 
• 65-85-0 benzoic acid 
• 105-67-9 2,4-Xylenol 
• 56-23-5 tetrachloromethane 
• 64-17-5 ethanol 
• 69-72-7 salicylic acid 
• 99-96-7 4-hydroxy-benzoic acid 
• 124-38-9 carbon dioxide 
• 108-95-2 phenol 
• 463-79-6 carbonic-acid 

Downstream Products

• 90844-13-6 4-hydroxyisophthalic acid 1-ethyl ester 
• 5985-25-1 4-hydroxy-1,3-benzenedicarboxylic acid diethyl ester 
• 616-76-2 2-hydroxy-5-formylbenzoic acid 
• 855641-74-6 5-formyl-4-hydroxy-isophthalic acid 
• 22235-27-4 4-hydroxy-5-nitro-isophthalic acid 
• 101567-41-3 4-hydroxy-cyclohexane-1,3-dicarboxylic acid 
• 54471-90-8 5-bromo-4-hydroxyisophthalic acid 
• 5985-26-2 4-(acetoxy)isophthalic acid 
• 103042-97-3 4-(2-diethylamino-ethoxy)-isophthalic acid bis-(2-diethylamino-ethyl ester) 
• 110052-27-2 4-hydroxy-isophthalic acid bis-(2-diethylamino-ethyl ester); dihydrochloride 
• 124-38-9 carbon dioxide 
• 108-95-2 phenol 
• 69-72-7 salicylic acid 
• 79128-78-2 2-hydroxy-5-(methoxycarbonyl)benzoic acid 

Relevant articles and documents

Method for extracting 4-hydroxy-m-phthalic acid from wintergreen oil production waste slag

The invention discloses a method for extracting 4-hydroxy-m-phthalic acid from wintergreen oil production waste slag. The method comprises the following steps: 1. extraction of 4-hydroxy-dimethyl isophthalate crude product from wintergreen oil production waste slag: dissolving wintergreen oil production waste slag in an organic solvent, heating, filtering while the solution is hot, standing the filtrate to precipitate a solid, and drying the filter cake to obtain the 4-hydroxy-dimethyl isophthalate crude product; 2. hydrolysis of 4-hydroxy-dimethyl isophthalate crude product: adding the 4-hydroxy-dimethyl isophthalate crude product into an alkali solution, heating for hydrolysis, cooling to room temperature, adding a decolorant for decolorization, regulating the pH value of the filtrate to 1-4, precipitating a solid under acidic conditions, collecting the filter cake, and carrying out vacuum drying. By recycling the wintergreen oil production waste slag, the method enhances the resource utilization rate and lowers the 4-hydroxy-m-phthalic acid production cost. Besides, the method has the advantages of high yield, high purity, simple technique, mild conditions, no side reaction and the like.

NOVEL CEPHALOSPORIN DERIVATIVE AND PHARMACEUTICAL COMPOSITION THEREOF

The present invention relates to novel cephalosporin derivatives represented by Chemical Formula 1. Wherein, X, Y, L, R1, and R2 are as same as defined in the description of the invention. The present invention also relates to pharmaceutical antibiotic compositions comprising a novel celphalosporin derivative represented by Chemical Formula 1, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof as an effective ingredient. According to the present invention, novel cephalosporin derivatives, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof as an effective ingredient for the broad spectrum of antibiotic resistant, low toxicity, particularly in Gram-negative bacteria, which can be useful with strong antimicrobial activity.