5418-94-0

Usage

Uses

Used in Pharmaceutical Industry:
2-a)pyrimidin-4-one,2-chloro-4h-pyrido( is used as an intermediate in the synthesis of pyrimidin-5-one derivatives, which are important for the development of various pharmaceutical compounds. These derivatives have potential applications in the treatment of different diseases, including cancer, due to their ability to modulate various biological pathways.
Used in Chemical Research:
2-a)pyrimidin-4-one,2-chloro-4h-pyrido( is also used as a research compound in the field of organic chemistry. Its unique structure makes it an interesting subject for studying the properties and reactivity of pyrimidinone and pyridine-containing compounds. This can lead to the discovery of new synthetic methods and applications for this class of compounds.

InChI:InChI=1/C8H5ClN2O/c9-6-5-8(12)11-4-2-1-3-7(11)10-6/h1-5H

Upstream product

• 27420-41-3 2-hydroxy-4H-pyrido<1,2-a>pyrimidin-4-one 
• 123419-89-6 2-Methylthio-4-oxo-4H-pyrido<1,2-a>pyrimidine-3-carboxylic acid 
• 138305-21-2 ethyl 3-oxo-3-(pyridin-2-ylamino)propianoate 
• 504-29-0 2-aminopyridine 
• 84292-17-1 2-(dimethylamino)-4H-pyrido<1,2-a>pyrimidin-4-one 
• 22288-66-0 2H,3H,4H-pyrido[1,2-a]pyrimidine-2,4-dione 
• 10025-87-3 trichlorophosphate 
• 237742-94-8 (2-pyridyl)iminopropadienone 
• 111680-69-4 2-chloro-N-phenyl-4H-pyrido<1,2-a>pyrimidin-4-imine 

Downstream Products

• 55395-30-7 2-hydrazinyl-4H-pyrido[1,2-a]pyrimidin-4-one 
• 17326-31-7 2-morfolino-4H-pirido<1,2-a>pirimidin-4-one 
• 84292-23-9 2-(diethylamino)-4H-pyrido<1,2-a>pyrimidin-4-one 
• 237742-94-8 (2-pyridyl)iminopropadienone 
• 16054-93-6 2-phenyl-4H-pyrido[1,2-a]pyrimidin-4-one 
• 1335239-80-9 2-(2'-acetylphenyl)-4H-pyrido[1,2-a]pyrimidin-4-one 
• 1335239-84-3 2-benzyl-4H-pyrido[1,2-a]pyrimidin-4-one 
• 1335239-79-6 2-[4-(trifluoromethyl)phenyl]-4H-pyrido[1,2-a]pyrimidin-4-one 
• 191218-37-8 2-(4'-methoxyphenyl)-4H-pyrido[1,2-a]pyrimidin-4-one 
• 867381-76-8 C₁₅H₁₀N₂O₃ 
• 1204420-27-8 3-(Hydroxymethyl)-2-phenoxy-4H-pyrido[1,2-a]pyrimidin-4-one 
• 685893-09-8 C₁₄H₁₀N₂O₂ 
• 1220910-27-9 4-imino-2-(methylthio)-5-oxo-1-phenyl-1,5-dihydro-4H-dipyrido-[1,2-a:2',3'-d]pyrimidine-3-carbonitrile 
• 33345-96-9 3-formyl-2-piperidino-4H-pyrido<1,2-a>pyrimidin-4-one 

Relevant academic research and scientific papers

QUINAZOLINONE COMPOUNDS AND DERIVATIVES THEREOF

Compounds of Formula I are useful inhibitors of tankyrase. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.

Substituted pyridopyrimidinones, 1: Convenient PTC alkylation and halogenation of 2-hydroxy-4H-pyrido[1,2-a]pyrimidin-4-one

Alkylation of 2-hydroxy-4H-pyrido[1,2-a]-pyrimidin-4-one (1) was investigated under solid-liquid phase transfer catalysis conditions (PTC), using tetrabutylammonium bromide and potassium carbonate. The reaction with alkyl halides led to the formation of various 2-alkoxy products, in fair yields. Reaction of compound 1 with epichlorohydrin and chloroacetonitrile, under the same PTC conditions, afforded novel O1,O3-disubstituted glycerol and oxazolopyridopyrimidone betaine derivatives, respectively. Some 3-halo-, 3,3-dihalo, and/or 2,3-dihalopyrido[1,2-a]pyrimidines were also prepared using different halogenating agents at different reaction conditions.

(2-Pyridyl)iminopropadienone

(2-Pyridyl)iminopropadienone 13 is generated by flash vacuum thermolysis (FVT) of 2-substituted pyrido[1,2-a]pyrimidin-4-ones 9 and observed by IR spectroscopy. Addition of HCl to 13 causes reversion to the starting material 9b, whereas addition of nucleophiles leads to malonic acid imide derivatives (23, 24, 26, 27, 28). The latter undergo thermal elimination of amines to regenerate 2-substituted pyridopyrimidinones. A competing retro-ene reaction occurs on FVT of 2-(dialkylamino)pyridopyrimidinones 9c,d, presumably in the oxoketenimine intermediates 22/25, with formation of the unsubstituted pyridopyrimidinone 31.

1,2-Fused Pyrimidines. III. Derivatives of 12H-Pyridopyrimidoquinoline, A Novel Heterocyclic System

Reactivities of 2-amino-4H-pyridopyrimidin-4-ones and 4-amino-2H-pyridopyrimidin-2-ones, both N,N-dialkyl and (N-alkyl,N-phenyl)substituted, when treated with the N,N-dimethylformamide/phosphorus oxychloride Vilsmeier-Haack reagent XII were