5418-94-0Relevant articles and documents
QUINAZOLINONE COMPOUNDS AND DERIVATIVES THEREOF
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, (2014/03/25)
Compounds of Formula I are useful inhibitors of tankyrase. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.
(2-Pyridyl)iminopropadienone
Plueg, Carsten,Frank, Wilhelm,Wentrup, Curt
, p. 1087 - 1094 (2007/10/03)
(2-Pyridyl)iminopropadienone 13 is generated by flash vacuum thermolysis (FVT) of 2-substituted pyrido[1,2-a]pyrimidin-4-ones 9 and observed by IR spectroscopy. Addition of HCl to 13 causes reversion to the starting material 9b, whereas addition of nucleophiles leads to malonic acid imide derivatives (23, 24, 26, 27, 28). The latter undergo thermal elimination of amines to regenerate 2-substituted pyridopyrimidinones. A competing retro-ene reaction occurs on FVT of 2-(dialkylamino)pyridopyrimidinones 9c,d, presumably in the oxoketenimine intermediates 22/25, with formation of the unsubstituted pyridopyrimidinone 31.