84292-23-9

Usage

Chemical class

Pyrido[1,2-a]pyrimidin-4-one derivatives

Pharmacological properties

Potential anti-cancer, anti-inflammatory, and anti-oxidant effects

Cancer cell growth inhibition

DEAPP has been shown to inhibit the growth of various cancer cell lines.

Apoptosis induction

DEAPP has been shown to induce apoptosis in cancer cells.

Neuroprotective agent

DEAPP has been suggested to be effective in treating neurodegenerative diseases.

Further research needed

The pharmacological properties and potential therapeutic applications of DEAPP are not yet fully understood.

Upstream product

• 504-29-0 2-aminopyridine 
• 33567-70-3 ethyl 3-(diethylamino)-3-oxopropanoate 
• 237742-94-8 (2-pyridyl)iminopropadienone 
• 123419-89-6 2-Methylthio-4-oxo-4H-pyrido<1,2-a>pyrimidine-3-carboxylic acid 
• 84292-17-1 2-(dimethylamino)-4H-pyrido<1,2-a>pyrimidin-4-one 
• 5418-94-0 2-chloro-4H-pyrido[1,2-a]pyrimidin-4-one 
• 109-89-7 diethylamine 

Downstream Products

• 237742-94-8 (2-pyridyl)iminopropadienone 

Relevant academic research and scientific papers

(2-Pyridyl)iminopropadienone

(2-Pyridyl)iminopropadienone 13 is generated by flash vacuum thermolysis (FVT) of 2-substituted pyrido[1,2-a]pyrimidin-4-ones 9 and observed by IR spectroscopy. Addition of HCl to 13 causes reversion to the starting material 9b, whereas addition of nucleophiles leads to malonic acid imide derivatives (23, 24, 26, 27, 28). The latter undergo thermal elimination of amines to regenerate 2-substituted pyridopyrimidinones. A competing retro-ene reaction occurs on FVT of 2-(dialkylamino)pyridopyrimidinones 9c,d, presumably in the oxoketenimine intermediates 22/25, with formation of the unsubstituted pyridopyrimidinone 31.

RICERCHE SU DERIVATI PIRIDOPIRIMIDINICI. Nota I - Sintesi di 4-(dialchilammino)-2H-piridopirimidin-2-oni.

Reaction of the N,N-dialkylethoxycarbonylacetamide-POCl3 reactant with 2-aminopyridine in refluxing dichloroethane yielded 4-(dialkylamino)-2H-pyridopyrimidine-2-ones (IV) together with generally lower quantities of isomeric 2-(dialkylamino)-4H-pyridopyrimidin-4-ones (V).Some compounds (V) were obtained also by reaction of 2-chloro-4H-pyridopyrimidin-4-one (VI) with the suitable amine in confirmation of their structure.In addition, the differences in the properties and in the spectroscopic characteristics of the two classes of isomers are reported.