54198-82-2

Basic information

• Product Name: 4-Chloro-6-methylpyrimidine
• Synonyms: 4-METHYL-6-CHLORO PYRIMIDINE;4-CHLORO-6-METHYLPYRIMIDINE;AKOS BBS-00002134;5-Chloro-4-methylpyrimidine;Pyrimidine, 5-chloro-4-methyl- (9CI);4-Methyl-5-chloro pyrimidine
• CAS NO: 54198-82-2
• Molecular Formula: C₅H₅ClN₂
• Molecular Weight: 128.56
• Product Categories: PYRIMIDINE;alkyl chloride
• Mol File: 54198-82-2.mol

Chemical Properties

• Melting Point: 151-152℃
• Boiling Point: 199.6°Cat760mmHg
• Flash Point: 92.8°C
• Appearance: /
• Density: 1.234
• Vapor Pressure: 0.479mmHg at 25°C
• Refractive Index: 1.529
• PKA: 0.50±0.16(Predicted)
• CAS DataBase Reference: 4-Chloro-6-methylpyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-6-methylpyrimidine(54198-82-2)
• EPA Substance Registry System: 4-Chloro-6-methylpyrimidine(54198-82-2)

Safety Data

• Hazardous Substances Data: 54198-82-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-Chloro-6-methylpyrimidine is used as a precursor in the synthesis of pharmaceuticals for its ability to contribute to the development of biologically active molecules. Its presence in the molecular structure of certain drugs aids in enhancing their therapeutic effects and properties.
Used in Pesticide Industry:
In the pesticide industry, 4-Chloro-6-methylpyrimidine is utilized as a starting material for the creation of various agrochemicals. Its reactivity and structural features allow for the production of compounds that are effective in controlling pests and protecting crops.
Used in Organic Synthesis:
4-Chloro-6-methylpyrimidine is employed as a valuable intermediate in organic synthesis. Its versatile nature enables the construction of a wide range of organic compounds, making it an indispensable tool for chemists in various research and development applications.

InChI:InChI=1/C5H5ClN2/c1-4-2-5(6)8-3-7-4/h2-3H,1H3

Upstream product

• 822-36-6 4-methyl-1H-imidazole 
• 67-66-3 chloroform 
• 83942-10-3 4,5-dichloro-6-methyl-pyrimidine 
• 1449706-97-1 5-chloro-4-methyl-4,5-dihydropyrimidine 

Downstream Products

• 114969-79-8 5-Chloro-4-methyl-pyrimidine-2-carbonitrile 
• 114969-84-5 5-Chloro-6-methyl-pyrimidine-4-carbonitrile 
• 114969-55-0 5-Chloro-4-methyl-pyrimidine 1-oxide 
• 114969-99-2 5-Chloro-4-methyl-pyrimidine 3-oxide 

Relevant articles and documents

HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF

Provided herein are thiophene compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.

Studies on Pyrimidine Derivatives. XXXIX. Site-Selectivity in the Reaction of 5-Substituted and 4,5-Disubstituted Pyrimidine N-Oxides with Trimethylsilyl Cynanide

The site-selectivity in the modified Reissert-Henze reaction of 5-substituted and 4,5-disubstituted pyrimidine 1-oxides with trimethylsilyl cyanide was examined.The reaction of 5-substituted 4-methoxypyrimidine 1-oxides with trimethylsilyl cyanide gave exclusively 2-pyrimidinecarbonitriles in good yields without exception.On the other hand, the other 5-substituted and 4,5-disubstituted pyrimidine 1-oxides gave mainly 6-pyrimidinecarbonitriles.Keywords--site-selectivity; pyrimidine N-oxide; trimethylsilyl cyanide; Reissert-Henze reasction; pyrimidinecarbonitrile

Reactions of Halogenomethanes in the Vapor Phase. Part 4. The Reactions of Imidazoles with Chloroform at 550 deg C, and a Comparison with their Liquid-phase Reactions with Trichloroacetate Ion or Hexachloroacetone and Base

1-Unsubstituted imidazoles and chloroform at 550 deg C in a flow system give mainly 5-chloropyrimidines, together with 4-chloropyrimidines and chloropyrazines.The effects of methyl substituents on the ratio of products is considered.The liquid-phase reactions of 2-methyl- and 2,4,5-trimethyl-imidazole under conditions in which dichlorocarbene is said to be formed in basic or neutral conditions were studied, and compared with the gas-phase reactions with chloroform.