54198-82-2

Basic information

• Product Name: 4-Chloro-6-methylpyrimidine
• Synonyms: 4-METHYL-6-CHLORO PYRIMIDINE;4-CHLORO-6-METHYLPYRIMIDINE;AKOS BBS-00002134;5-Chloro-4-methylpyrimidine;Pyrimidine, 5-chloro-4-methyl- (9CI);4-Methyl-5-chloro pyrimidine
• CAS NO: 54198-82-2
• Molecular Formula: C₅H₅ClN₂
• Molecular Weight: 128.56
• Product Categories: PYRIMIDINE;alkyl chloride
• Mol File: 54198-82-2.mol
• Article Data: 3

Chemical Properties

• Melting Point: 151-152℃
• Boiling Point: 199.6°Cat760mmHg
• Flash Point: 92.8°C
• Appearance: /
• Density: 1.234
• Vapor Pressure: 0.479mmHg at 25°C
• Refractive Index: 1.529
• PKA: 0.50±0.16(Predicted)
• CAS DataBase Reference: 4-Chloro-6-methylpyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-6-methylpyrimidine(54198-82-2)
• EPA Substance Registry System: 4-Chloro-6-methylpyrimidine(54198-82-2)

Safety Data

• Hazardous Substances Data: 54198-82-2(Hazardous Substances Data)

Usage

General Description

4-Chloro-6-methylpyrimidine is a chemical compound with the molecular formula C5H5ClN2. It is a heterocyclic organic compound that contains both chlorine and methyl functional groups. This chemical is commonly used as a precursor in the synthesis of pharmaceuticals, pesticides, and other organic compounds. Its structure and reactivity make it a useful building block for the construction of various biologically active molecules. 4-Chloro-6-methylpyrimidine is considered to be a key intermediate in the production of many important compounds, and its versatile nature makes it a valuable tool in organic synthesis.

InChI:InChI=1/C5H5ClN2/c1-4-2-5(6)8-3-7-4/h2-3H,1H3

Upstream product

• 1449706-97-1 5-chloro-4-methyl-4,5-dihydropyrimidine 
• 83942-10-3 4,5-dichloro-6-methyl-pyrimidine 
• 822-36-6 4-methyl-1H-imidazole 
• 67-66-3 chloroform 

Downstream Products

• 114969-84-5 5-Chloro-6-methyl-pyrimidine-4-carbonitrile 
• 114969-79-8 5-Chloro-4-methyl-pyrimidine-2-carbonitrile 
• 114969-55-0 5-Chloro-4-methyl-pyrimidine 1-oxide 
• 114969-99-2 5-Chloro-4-methyl-pyrimidine 3-oxide 

Relevant articles and documents

HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF

Provided herein are thiophene compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.

Reactions of Halogenomethanes in the Vapor Phase. Part 4. The Reactions of Imidazoles with Chloroform at 550 deg C, and a Comparison with their Liquid-phase Reactions with Trichloroacetate Ion or Hexachloroacetone and Base

1-Unsubstituted imidazoles and chloroform at 550 deg C in a flow system give mainly 5-chloropyrimidines, together with 4-chloropyrimidines and chloropyrazines.The effects of methyl substituents on the ratio of products is considered.The liquid-phase reactions of 2-methyl- and 2,4,5-trimethyl-imidazole under conditions in which dichlorocarbene is said to be formed in basic or neutral conditions were studied, and compared with the gas-phase reactions with chloroform.