54198-88-8

Usage

Uses

Used in Pharmaceutical Industry:
2-(Chloromethyl)pyrimidine is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to undergo diverse chemical transformations. Its reactivity facilitates the development of new drugs with improved therapeutic properties and efficacy.
Used in Agrochemical Industry:
In the agrochemical sector, 2-(Chloromethyl)pyrimidine is utilized as a reactive intermediate in the production of agrochemicals, contributing to the creation of innovative and effective crop protection agents.
Used in Specialty Chemicals Industry:
2-(Chloromethyl)pyrimidine is employed as a building block in the synthesis of specialty chemicals, where its reactivity and ability to participate in various chemical reactions are harnessed to develop new materials with unique properties and applications.
Overall, the versatility and reactivity of 2-(Chloromethyl)pyrimidine make it an indispensable component in the development of new drugs, agrochemicals, and specialty chemicals, underscoring its importance in the pharmaceutical and chemical industries.

InChI:InChI=1/C5H5ClN2/c6-4-5-7-2-1-3-8-5/h1-3H,4H2

Upstream product

• 5053-43-0 2-methylpyrimidine 
• 87-90-1 trichloroisocyanuric acid 
• 22433-12-1 (5-bromopyrimidine-2-yl)methanol 

Downstream Products

• 126230-86-2 2-(2-propynyloxymethyl)pyrimidine 
• 497852-18-3 7-{4-[2-(butoxy)ethoxy]phenyl}-1-isobutyl-N-({4-[(2-pyrimidinyl)methyl]sulfanyl}phenyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide 
• 59566-45-9 2-(pyrimidin-2-yl)acetonitrile 
• 99650-08-5 triphenyl(pyrimidin-2-ylmethyl)phosphonium chloride 
• 1346698-85-8 5-ethyl-6-{2-[4-(pyrimidin-2-ylmethoxy)phenyl]benzoxazol-6-yl}-4,5-dihydro-2H-pyridazin-3-one 
• 1293395-66-0 4-{4-(4-fluorophenyl)-1-[1-(pyrimidin-2-ylmethyl)piperidin-4-yl]-1H-imidazol-5-yl}pyrimidin-2-amine 
• 1174681-19-6 1-[4-(pyrimidin-2-ylmethoxy)phenyl]-1,2,3,4-tetrahydroquinoxaline 
• 60561-50-4 methyl 2-(pyrimidin-2-yl)acetate 

Relevant academic research and scientific papers

Discovery of functionally selective 7,8,9,10-tetrahydro-7,10-ethano-1,2,4- triazolo[3,4-a]phthalazines as GABAA receptor agonists at the α3 subunit

We have previously identified the 7,8,9,10-tetrahydro-7,10-ethano-1,2,4- triazolo[3,4-a]phthalazine (1) as a potent partial agonist for the 0.3 receptor subtype with 5-fold selectivity in binding affinity over α1. This paper describes a detailed investigation of the substituents on this core structure at both the 3- and 6-positions. Despite evaluating a wide range of groups, the maximum selectivity that could be achieved in terms of affinity for the α3 subtype over the α1 subtype was 12-fold (for 57). Although most analogues showed no selectivity in terms of efficacy, some did show partial agonism at α1 and antagonism at α3 (e.g., 25 and 75). However, two analogues tested (93 and 96), both with triazole substituents in the 6-position, showed significantly higher efficacy for the α3 subtype over the α1 subtype. This was the first indication that selectivity in efficacy in the required direction could be achieved in this series.

Substituted triazolo-pyridazine derivatives as ligands for GABA receptors

Substituted triazolo-pyridazine derivative compounds represented by wherein the variables are disclosed herein are selective ligands for GABA-A receptors, particularly for the α2 and/or α3 subunits.

PHARMACOLOGICALLY ACTIVE GUANIDINE COMPOUNDS

The compounds are substituted thioalkyl-, aminoalkyl-and oxyalkyl-guanidines which are inhibitors of histamine activity.