59566-45-9

Usage

Uses

Used in Pharmaceutical Industry:
2-Pyrimidineacetonitrile (9CI) is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs. Its unique chemical structure allows it to be a building block in the creation of molecules with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Pyrimidineacetonitrile (9CI) serves as an intermediate in the production of agrochemicals, helping to develop compounds that can be used in pest control and crop protection, thereby enhancing agricultural productivity.
Used in Fine Chemicals Synthesis:
2-Pyrimidineacetonitrile (9CI) is utilized as an intermediate in the synthesis of fine chemicals, which are high-purity chemicals used in various applications such as fragrances, dyes, and other specialty chemical products.
Used in Biological Research:
2-Pyrimidineacetonitrile (9CI) is studied for its potential biological activities, including its use as an enzyme inhibitor. This makes it a valuable compound in the research and development of new therapeutic agents and understanding biological processes.
Used in Anti-Cancer Research:
As a potential anti-cancer agent, 2-Pyrimidineacetonitrile (9CI) is explored for its capacity to inhibit the growth of cancer cells. Its role in this area is significant for developing new strategies in cancer treatment and management.

Upstream product

• 63155-43-1 2-(4,6-dichloropyrimidin-2-yl)acetonitrile 
• 54198-88-8 2-chloromethylpyrimidine 
• 42839-09-8 2-pyrimidinemethanol 
• 28215-45-4 2-(4,6-dihydroxypyrimidin-2-yl)acetamide 
• 497-19-8 sodium carbonate 

Downstream Products

• 60561-50-4 methyl 2-(pyrimidin-2-yl)acetate 

Relevant academic research and scientific papers

Modulating Photostability and Mitochondria Selectivity in Far-Red/NIR Emitting Coumarin Fluorophores through Replacement of Pyridinium by Pyrimidinium

Mitochondrial dysfunction has been associated with several human pathological conditions, including cancer, aging, and neurodegenerative diseases. Thus, the availability of selective fluorescent probes for mitochondria could play an important role in the future for monitoring cellular functions and disease progression. In this work, we have studied how the photophysical properties and subcellular accumulation of nonconventional coumarin-based COUPY fluorophores can be fine-tuned through replacement of the para-pyridinium moiety with several heterocycles. Among them, ortho,para-pyrimidinium substitution provided novel fluorophores with suitable photophysical properties for bioimaging applications, including emission in the far-red to NIR region, large Stokes' shifts, and high photostability. Furthermore, the compounds exhibited excellent cell membrane permeability in living cells and a higher selectivity for mitochondria compared with the parent COUPY fluorophores. Overall, these results provided useful insights into the development of novel mitochondria-targeted fluorescent probes based on small organic molecules, since higher selectivity for this organelle can be achieved through the replacement of conventional N-alkylated pyridinium moieties by the corresponding N-alkylated-ortho,para-pyrimidinium counterparts.

FTO INHIBITORS

The invention provides compounds that inhibit FTO (fat mass and obesity), including pharmaceutically acceptable salts, hydrides and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof, particularly obesity, with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.

Benzamide derivatives and uses related thereto

Benzamide derivatives of formula I are described and have therapeutic utility, particularly in the treatment of diabetes, obesity and related conditions and disorders: wherein R1, R2, R3, R4, R5, R6, R7, R8, and n are as defined herein.

3-Morpholino-2-heterocyclic-thiopropanamides

The compounds are 3-morpholino-2-heterocyclicthiopropanamides which are inhibitors of gastric acid secretion.

2-Alkoxy(and 2-alkoxyalkyl)-2-heterocyclic-thioacetamides for inhibiting gastric acid secretion

The compounds are 2-alkoxy(and 2-alkoxyalkyl)-2-heterocyclic-thioacetamides which are inhibitors of gastric acid secretion.