59566-45-9

Basic information

• Product Name: 2-Pyrimidineacetonitrile (9CI)
• Synonyms: 2-Pyrimidineacetonitrile (9CI);2-Pyrimidinylacetonitrile;EOS-62028;2-(pyrimidin-2-yl)acetonitrile HCl
• CAS NO: 59566-45-9
• Molecular Formula: C₆H₅N₃
• Molecular Weight: 119.124
• Product Categories: PYRIMIDINE
• Mol File: 59566-45-9.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Pyrimidineacetonitrile (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyrimidineacetonitrile (9CI)(59566-45-9)
• EPA Substance Registry System: 2-Pyrimidineacetonitrile (9CI)(59566-45-9)

Safety Data

• Hazardous Substances Data: 59566-45-9(Hazardous Substances Data)

Usage

General Description

2-Pyrimidineacetonitrile (9CI) is a chemical compound with the molecular formula C6H4N2. It is a nitrile derivative of pyrimidine, and is also known by the systematic name 2-cyanopyrimidine. 2-Pyrimidineacetonitrile (9CI) is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. It has also been studied for its potential biological activities, including its use as an inhibitor of enzymes and as a potential anti-cancer agent. 2-Pyrimidineacetonitrile (9CI) is a colorless to pale yellow liquid, and its properties make it a versatile compound in various chemical processes.

Upstream product

• 63155-43-1 2-(4,6-dichloropyrimidin-2-yl)acetonitrile 
• 54198-88-8 2-chloromethylpyrimidine 
• 42839-09-8 2-pyrimidinemethanol 
• 28215-45-4 2-(4,6-dihydroxypyrimidin-2-yl)acetamide 
• 497-19-8 sodium carbonate 

Downstream Products

• 60561-50-4 methyl 2-(pyrimidin-2-yl)acetate 

Relevant articles and documents

Modulating Photostability and Mitochondria Selectivity in Far-Red/NIR Emitting Coumarin Fluorophores through Replacement of Pyridinium by Pyrimidinium

Mitochondrial dysfunction has been associated with several human pathological conditions, including cancer, aging, and neurodegenerative diseases. Thus, the availability of selective fluorescent probes for mitochondria could play an important role in the future for monitoring cellular functions and disease progression. In this work, we have studied how the photophysical properties and subcellular accumulation of nonconventional coumarin-based COUPY fluorophores can be fine-tuned through replacement of the para-pyridinium moiety with several heterocycles. Among them, ortho,para-pyrimidinium substitution provided novel fluorophores with suitable photophysical properties for bioimaging applications, including emission in the far-red to NIR region, large Stokes' shifts, and high photostability. Furthermore, the compounds exhibited excellent cell membrane permeability in living cells and a higher selectivity for mitochondria compared with the parent COUPY fluorophores. Overall, these results provided useful insights into the development of novel mitochondria-targeted fluorescent probes based on small organic molecules, since higher selectivity for this organelle can be achieved through the replacement of conventional N-alkylated pyridinium moieties by the corresponding N-alkylated-ortho,para-pyrimidinium counterparts.

Benzamide derivatives and uses related thereto

Benzamide derivatives of formula I are described and have therapeutic utility, particularly in the treatment of diabetes, obesity and related conditions and disorders: wherein R1, R2, R3, R4, R5, R6, R7, R8, and n are as defined herein.

2-Alkoxy(and 2-alkoxyalkyl)-2-heterocyclic-thioacetamides for inhibiting gastric acid secretion

The compounds are 2-alkoxy(and 2-alkoxyalkyl)-2-heterocyclic-thioacetamides which are inhibitors of gastric acid secretion.