54199-54-1Relevant academic research and scientific papers
Base-promoted thioannulation of: O -alkynyl oxime ethers with sodium sulfide for the general synthesis of isothiocoumarins
Sun, Cai-Ling,Zhang, Xiao-Hong,Zhang, Xing-Guo,Zhang, Zhu-Zhu
, p. 10174 - 10180 (2021/12/10)
A general and efficient strategy for the one-pot synthesis of isothiocoumarin-1-ones has been developed via the base-promoted 6-endo-dig thioannulation of o-alkynyl oxime ethers using the cheap and readily available Na2S as the sulfur source. Mechanistic studies disclosed that the reaction proceeded through two C-S bond formations, N-O bond cleavage and the final hydrolysis of imines. This journal is
