54199-68-7Relevant academic research and scientific papers
Base-promoted thioannulation of: O -alkynyl oxime ethers with sodium sulfide for the general synthesis of isothiocoumarins
Sun, Cai-Ling,Zhang, Xiao-Hong,Zhang, Xing-Guo,Zhang, Zhu-Zhu
supporting information, p. 10174 - 10180 (2021/12/10)
A general and efficient strategy for the one-pot synthesis of isothiocoumarin-1-ones has been developed via the base-promoted 6-endo-dig thioannulation of o-alkynyl oxime ethers using the cheap and readily available Na2S as the sulfur source. Mechanistic studies disclosed that the reaction proceeded through two C-S bond formations, N-O bond cleavage and the final hydrolysis of imines. This journal is
A new and concise synthesis of 3-aryl- and 3-alkyl-1H-2-benzothiopyran-1-ones (Thioisocoumarins)
Couture,Cornet,Grandclaudon
, p. 1133 - 1134 (2007/10/02)
3-Aryl-and 3-alkyl-1H-2-benzothiopyran-1-ones are readily accessible by reaction of the lithiated N,N-diethyl-o-toluamide (N,N-diethyl-2-methylbenzenecarboxamide) with appropriate aromatic, heteroaromatic and aliphatic thioesters.
