5422-27-5

Usage

Uses

Used in Pharmaceutical Industry:
5-cyclopentylpentanoic acid serves as a crucial intermediate in the synthesis of a variety of drugs. Its unique structure allows for the creation of diverse medicinal compounds, contributing to the development of new therapeutic agents.
Used in Medicinal Chemistry Research:
5-cyclopentylpentanoic acid is utilized as a starting material for the preparation of esters, amides, and other derivatives, which are essential in the exploration of novel chemical entities with potential therapeutic benefits.
Used in Biological Activity Studies:
5-cyclopentylpentanoic acid has been investigated for its potential anti-inflammatory and anticonvulsant properties, indicating its importance in the discovery of new treatments for inflammatory conditions and seizure disorders.

Upstream product

• 75649-60-4 6-cyclopent-1-enyl-tetrahydro-pyran-2-one 
• 34094-20-7 (3-bromo-propyl)-cyclopentane 
• 3524-75-2 allylcyclopentane 
• 140-77-2 3-cyclopentylpropionic acid 
• 106211-63-6 3-cyclopentyl-1-iodopropane 
• 767-05-5 3-cyclopentyl-1-propanol 
• 2146-27-2 5-cyclopentyl-valeric acid methyl ester 
• 142-29-0 cyclopentene 
• 91352-29-3 5-cyclopent-1-enyl-5-oxo-valeric acid methyl ester 
• 1501-26-4 methyl 4-(chlorocarbonyl)butyrate 
• 120-92-3 cyclopentanone 
• 17814-85-6 (4-carboxybutyl)triphenylphosphonium bromide 
• 6050-30-2 5-cyclopentylidene-pentanoic acid 
• 854412-26-3 5-cyclopentyl-4-oxo-valeric acid ethyl ester 

Downstream Products

• 463927-89-1 C₂₃H₃₂N₂O₄S 
• 15096-84-1 5-cyclopentyl-valeric acid anilide 

Relevant academic research and scientific papers

Palladium(II)-Catalyzed Enantioselective Arylation of Unbiased Methylene C(sp3)?H Bonds Enabled by a 2-Pyridinylisopropyl Auxiliary and Chiral Phosphoric Acids

Enantioselective functionalizations of unbiased methylene C(sp3)?H bonds of linear systems by metal insertion are intrinsically challenging and remain a largely unsolved problem. Herein, we report a palladium(II)-catalyzed enantioselective arylation of unbiased methylene β-C(sp3)?H bonds enabled by the combination of a strongly coordinating bidentate PIP auxiliary with a monodentate chiral phosphoric acid (CPA). The synergistic effect between the PIP auxiliary and the non-C2-symmetric CPA is crucial for effective stereocontrol. A broad range of aliphatic carboxylic acids and aryl bromides can be used, providing β-arylated aliphatic carboxylic acid derivatives in high yields (up to 96 %) with good enantioselectivities (up to 95:5 e.r.). Notably, this reaction also represents the first palladium(II)-catalyzed enantioselective C?H activation with less reactive and cost-effective aryl bromides as the arylating reagents. Mechanistic studies suggest that a single CPA is involved in the stereodetermining C?H palladation step.

DESIGN AND SYNTHESIS OF OPTIMIZED LIGANDS FOR PPAR

This invention provides new chemical entities useful for treating a variety of clinical disorders including those that areinfluenced by the activity of peroxisome proliferator activated receptors (PPAR). The structures of the compounds and methods to design, make and use the compounds are provided. Compounds and methods for administering therapeutic compositions comprising the compounds in cases of the disease psoriasis are provided. An exemplary compound having the formula compound is 5-adamantan-2-yl-pentanoic acid {2-[4-(2,4-dioxo-thiazolidin-5-yl-methyl)-phenoxy]-ethyl}-methyl-amide is provided.

Novel potent inhibitors of lipid peroxidation with protective effects against reperfusion arrhythmias

A series of new compounds that contain lipoic acid and trolox connected through spacers were synthesized and examined for their antioxidant activity and their protective effects against reperfusion arrhythmias in isolated heart preparations. All compounds